| Literature DB >> 23101866 |
A Gholipour-Kanani1, S H Bahrami, A Samadi-Kochaksaraie, H Ahmadi-Tafti, S Rabbani, A Kororian, E Erfani.
Abstract
Chitosan-poly(vinyl alcohol) (Cs:PVA) nanofibrous scaffolds were electrospun from 2:3 (wt/wt) Cs:PVA solution dissolved in 80% acetic acid. In vivo study was carried out on the dorsum skin of rat which burnt with a hot brass cylinder. The scaffolds were applied in two forms, that is, acellular (n=6) and cell-seeded with mesenchymal stem cells (n=6). Macroscopic measurements of wound area showed good aspect healing effect of scaffolds in comparison with control wounds specially in 15 days post operating. Pathological studies were done on the wounds to investigate the healing effects. The healing process of the wound covered with Cs/PVA nanofibrous scaffolds was much rapid compared to untreated wounds. However, the presence of stem cells on this scaffolds accelerated the wound healing process owing to their ability of collagen regeneration.Entities:
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Year: 2012 PMID： 23101866 DOI： 10.1049/iet-nbt.2011.0070
Source DB: PubMed Journal: IET Nanobiotechnol ISSN： 1751-8741 Impact factor: 1.847