AIM: Angiogenesis is the formation of new blood vessels from preexisting one. The angiopoietins act a central role in these process. The aim of the present study is to the assess the impact of the circulating levels of angiopoietin-1 (Angi-1), Angiopoietin-2 (Angi-2), soluble Tie2 receptor (sTie2), and calculated Angi-2/sTie2 ratio on overall survival in 71 acute myeloid leukemia patients and 19 normal controls. MATERIALS AND METHODS: Ang-2, and calculated angi-2/sTie values were significantly higher in AML patients as compared to healthy volunteer (P= 0.002, 0.015 respectively) on the other hand Angi-1 was not significantly different in patients and control. RESULTS: In univariate Cox proportional hazards model Angi-2, sTie2, angi-2/sTie2 ratio were predictive of poor survival. In multivariate analysis the calculated angi-2/sTie2 ratio is independent prognostic factor, with relative risk of 3.939, with 95% confidence interval 0.002-0.001. CONCLUSION: The calculated angiopoietin-2/sTie2 ratio represent an independent prognostic factor in AML and its value should be considered when considering anti angiogenic therapy.
AIM: Angiogenesis is the formation of new blood vessels from preexisting one. The angiopoietins act a central role in these process. The aim of the present study is to the assess the impact of the circulating levels of angiopoietin-1 (Angi-1), Angiopoietin-2 (Angi-2), soluble Tie2 receptor (sTie2), and calculated Angi-2/sTie2 ratio on overall survival in 71 acute myeloid leukemiapatients and 19 normal controls. MATERIALS AND METHODS:Ang-2, and calculated angi-2/sTie values were significantly higher in AMLpatients as compared to healthy volunteer (P= 0.002, 0.015 respectively) on the other hand Angi-1 was not significantly different in patients and control. RESULTS: In univariate Cox proportional hazards model Angi-2, sTie2, angi-2/sTie2 ratio were predictive of poor survival. In multivariate analysis the calculated angi-2/sTie2 ratio is independent prognostic factor, with relative risk of 3.939, with 95% confidence interval 0.002-0.001. CONCLUSION: The calculated angiopoietin-2/sTie2 ratio represent an independent prognostic factor in AML and its value should be considered when considering anti angiogenic therapy.
Authors: C Schliemann; R Bieker; N Thoennissen; J Gerss; R Liersch; T Kessler; T Büchner; W E Berdel; R M Mesters Journal: Leukemia Date: 2007-06-28 Impact factor: 11.528
Authors: Jonathan Oliner; Hosung Min; Juan Leal; Dongyin Yu; Shashirekha Rao; Edward You; Xiu Tang; Haejin Kim; Susanne Meyer; Seog Joon Han; Nessa Hawkins; Robert Rosenfeld; Elyse Davy; Kevin Graham; Frederick Jacobsen; Shirley Stevenson; Joanne Ho; Qing Chen; Thomas Hartmann; Mark Michaels; Michael Kelley; Luke Li; Karen Sitney; Frank Martin; Ji-Rong Sun; Nancy Zhang; John Lu; Juan Estrada; Rakesh Kumar; Angela Coxon; Stephen Kaufman; James Pretorius; Sheila Scully; Russ Cattley; Marc Payton; Steve Coats; Linh Nguyen; Binodh Desilva; Anthony Ndifor; Isaac Hayward; Robert Radinsky; Tom Boone; Richard Kendall Journal: Cancer Cell Date: 2004-11 Impact factor: 31.743