Literature DB >> 23100863

Characterisation of the canine cardiac sarcolemma in experimental myocardial ischemia.

T J Netticadan1, T F Ashavaid, K G Nair.   

Abstract

The cardiac sarcolemma was characterized in 13 normal and 11 ischemic dog hearts by enzyme analysis and compositional assays. Significant decreases in the activities of the sodium-potassium and calcium pumps and structural compositional disturbances were observed in ischemia. High concentrations of oleic acid, a fatty acid and palmitoyl carnitine, a fatty acid intermediate caused inhibition of the enzyme pump activities of the normal sarcolemma. Thus, ischemia results in the functional impairment of the sarcolemma. Accumulation of fatty acid and fatty acid intermediates, occurring in myocardial ischemia, could be an underlying mechanism.

Entities:  

Keywords:  Myocardial ischaemia; canine cardiac sarcolemma

Year:  1997        PMID： 23100863      PMCID： PMC3454035          DOI： 10.1007/BF02867955

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  25 in total

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Journal:  J Mol Cell Cardiol       Date:  1988-03       Impact factor: 5.000

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  3 in total

Review 1.  Sarcolemmal dependence of cardiac protection and stress-resistance: roles in aged or diseased hearts.

Authors:  Louise E See Hoe; Lauren T May; John P Headrick; Jason N Peart
Journal:  Br J Pharmacol       Date:  2016-09-09       Impact factor: 8.739

2.  Interplay of cholesterol, membrane bilayers and the AT1R: A cholesterol consensus motif on AT1R is revealed.

Authors:  Sofia Kiriakidi; Christos Chatzigiannis; Christina Papaemmanouil; Andreas G Tzakos; Zoe Cournia; Thomas Mavromoustakos
Journal:  Comput Struct Biotechnol J       Date:  2020-12-03       Impact factor: 7.271

3.  The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan.

Authors:  Dimitrios Ntountaniotis; Tahsin Kellici; Andreas Tzakos; Pinelopi Kolokotroni; Theodore Tselios; Johanna Becker-Baldus; Clemens Glaubitz; Sonyan Lin; Alexandros Makriyannis; Thomas Mavromoustakos
Journal:  Biochim Biophys Acta       Date:  2014-06-16
  3 in total

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