Literature DB >> 23100713

Functional genomics as a tool in virus research.

Ruchi Ratra1, Sunil K Lal.   

Abstract

Genomics is the study of an organism's entire genome. It started out as a great scientific endeavor in the 1990s which aimed to sequence the complete genomes of certain biological species. However viruses are not new to this field as complete viral genomes have routinely been sequenced since the past thirty years. The 'genomic era' has been said to have revolutionized biology. This knowledge of full genomes has created the field of functional genomics in today's post-genomic era, which, is in most part concerned with the studies on the expression of the organism's genome under different conditions. This article is an attempt to introduce its readers to the application of functional genomics to address and answer several complex biological issues in virus research.

Entities:  

Keywords:  DNA microarray; Functional genomics; Virus; Virus-host interaction

Year:  2008        PMID: 23100713      PMCID: PMC3450177          DOI: 10.1007/s12088-008-0032-3

Source DB:  PubMed          Journal:  Indian J Microbiol        ISSN: 0046-8991            Impact factor:   2.461


  60 in total

1.  In vivo DNA expression of functional brome mosaic virus RNA replicons in Saccharomyces cerevisiae.

Authors:  M Ishikawa; M Janda; M A Krol; P Ahlquist
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

2.  Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays.

Authors:  H Zhu; J P Cong; G Mamtora; T Gingeras; T Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

3.  Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays.

Authors:  M J Kozal; N Shah; N Shen; R Yang; R Fucini; T C Merigan; D D Richman; D Morris; E Hubbell; M Chee; T R Gingeras
Journal:  Nat Med       Date:  1996-07       Impact factor: 53.440

Review 4.  A genomic perspective on protein families.

Authors:  R L Tatusov; E V Koonin; D J Lipman
Journal:  Science       Date:  1997-10-24       Impact factor: 47.728

5.  Functional genomics: it's all how you read it.

Authors:  P Hieter; M Boguski
Journal:  Science       Date:  1997-10-24       Impact factor: 47.728

6.  Nucleotide sequence of bacteriophage phi X174 DNA.

Authors:  F Sanger; G M Air; B G Barrell; N L Brown; A R Coulson; C A Fiddes; C A Hutchison; P M Slocombe; M Smith
Journal:  Nature       Date:  1977-02-24       Impact factor: 49.962

7.  Serial analysis of gene expression.

Authors:  V E Velculescu; L Zhang; B Vogelstein; K W Kinzler
Journal:  Science       Date:  1995-10-20       Impact factor: 47.728

8.  Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses.

Authors:  D J McGeoch; S Cook; A Dolan; F E Jamieson; E A Telford
Journal:  J Mol Biol       Date:  1995-03-31       Impact factor: 5.469

Review 9.  DNA chips: state-of-the art.

Authors:  G Ramsay
Journal:  Nat Biotechnol       Date:  1998-01       Impact factor: 54.908

10.  Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene.

Authors:  W Fiers; R Contreras; F Duerinck; G Haegeman; D Iserentant; J Merregaert; W Min Jou; F Molemans; A Raeymaekers; A Van den Berghe; G Volckaert; M Ysebaert
Journal:  Nature       Date:  1976-04-08       Impact factor: 49.962

View more
  1 in total

1.  Microbiological identification and analysis of Swine lungs collected from carcasses in Swine farms, china.

Authors:  Yunfeng Zha; Jiexiong Xie; Ye Chen; Chunya Wei; Wanjun Zhu; Jidang Chen; Haitao Qi; Liangquan Zhang; Long Sun; Xiaozhan Zhang; Pei Zhou; Zhenpeng Cao; Wenbao Qi; Minze Zhang; Zhen Huang; Guihong Zhang
Journal:  Indian J Microbiol       Date:  2013-03-27       Impact factor: 2.461

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.