Shin Hye Kim1, Min Kyung Oh2, Ran Namgung3, Mi Jung Park1. 1. 1 Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, 761-1 Sanggye-7-dong, Nowon-gu, Seoul 139-707, Republic of Korea. 2. 2 Clinical Trial Center, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea. 3. 3 Department of Pediatrics, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemung-gu, Seoul 120-752, Republic of Korea.
Abstract
OBJECTIVE: We aimed to assess the prevalence and associated factors of vitamin D deficiency in healthy adolescents and to determine parent-adolescent association in vitamin D status. DESIGN: A cross-sectional study. SETTING: Data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2009. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured using 125I-labelled RIA kits. Vitamin D deficiency in adolescents was defined as 25(OH)D level <27·5 nmol/l, and 25(OH)D levels between 27·5 and <50 nmol/l were considered insufficient. For the parents, vitamin D deficiency was defined as 25(OH)D level <50 nmol/l. SUBJECTS: The study population consisted of 2062 adolescents (1095 boys, 967 girls; aged 10-18 years) and their parents (1005 fathers, 1341 mothers). RESULTS: Overall, 13·4% of adolescents (boys 11·7%, girls 15·4%) were 25(OH)D deficient, 54·7% were 25(OH)D insufficient. Prevalence of vitamin D deficiency increased with age (P < 0·0001). Parental vitamin D deficiency was more prevalent in vitamin D-deficient adolescents than in non-deficient adolescents (all P < 0·0001). In multivariate logistic regression analyses, predictors for vitamin D deficiency were senior high school students (OR = 3·45-4·33), winter/spring season (OR = 3·18-5·11/5·35-7·36) and parental vitamin D deficiency (OR = 1·78-4·88; all P < 0·05). CONCLUSIONS: Vitamin D insufficiency is prevalent among healthy Korean adolescents and the parent-offspring association warrants vitamin D screening for family members of deficient individuals.
OBJECTIVE: We aimed to assess the prevalence and associated factors of vitamin D deficiency in healthy adolescents and to determine parent-adolescent association in vitamin D status. DESIGN: A cross-sectional study. SETTING: Data from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2009. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured using 125I-labelled RIA kits. Vitamin D deficiency in adolescents was defined as 25(OH)D level <27·5 nmol/l, and 25(OH)D levels between 27·5 and <50 nmol/l were considered insufficient. For the parents, vitamin D deficiency was defined as 25(OH)D level <50 nmol/l. SUBJECTS: The study population consisted of 2062 adolescents (1095 boys, 967 girls; aged 10-18 years) and their parents (1005 fathers, 1341 mothers). RESULTS: Overall, 13·4% of adolescents (boys 11·7%, girls 15·4%) were 25(OH)D deficient, 54·7% were 25(OH)D insufficient. Prevalence of vitamin D deficiency increased with age (P < 0·0001). Parental vitamin D deficiency was more prevalent in vitamin D-deficient adolescents than in non-deficient adolescents (all P < 0·0001). In multivariate logistic regression analyses, predictors for vitamin D deficiency were senior high school students (OR = 3·45-4·33), winter/spring season (OR = 3·18-5·11/5·35-7·36) and parental vitamin D deficiency (OR = 1·78-4·88; all P < 0·05). CONCLUSIONS:Vitamin Dinsufficiency is prevalent among healthy Korean adolescents and the parent-offspring association warrants vitamin D screening for family members of deficient individuals.
Authors: Giuseppe Saggese; Francesco Vierucci; Annemieke M Boot; Justyna Czech-Kowalska; Giovanna Weber; Carlos A Camargo; Eric Mallet; Margherita Fanos; Nick J Shaw; Michael F Holick Journal: Eur J Pediatr Date: 2015-04-02 Impact factor: 3.183
Authors: Francesco Vierucci; Marta Del Pistoia; Margherita Fanos; Martina Gori; Giorgia Carlone; Paola Erba; Gabriele Massimetti; Giovanni Federico; Giuseppe Saggese Journal: Eur J Pediatr Date: 2013-12 Impact factor: 3.183
Authors: Mathias Steinach; Eberhard Kohlberg; Martina Anna Maggioni; Stefan Mendt; Oliver Opatz; Alexander Stahn; Josefine Tiedemann; Hanns-Christian Gunga Journal: PLoS One Date: 2015-12-07 Impact factor: 3.240