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Literature DB >> 23098299

A versatile monoclonal antibody specific to human SERPINB5.

Sonia S Y Teoh¹, Hong Wang, Gail P Risbridger, James C Whisstock, Phillip I Bird.

Abstract

Maspin (SERPINB5) is a member of the Clade B subgroup of the large superfamily of serine protease inhibitors. It is proposed that maspin is a tumor suppressor; however, its molecular role remains to be elucidated. Here we report the characterization of a mouse monoclonal antibody directed against human maspin. This antibody, 16F7, recognizes maspin in both its native and denatured form, unlike several other commercial antibodies tested in this study. It will be a useful and versatile tool for future analyses of the biological function of maspin.

Entities: Disease Gene Species

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Year: 2012 PMID： 23098299 PMCID： PMC3482377 DOI： 10.1089/hyb.2012.0035

Source DB: PubMed Journal: Hybridoma (Larchmt) ISSN： 1554-0014

24 in total

1. Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

Authors: J A Irving; R N Pike; A M Lesk; J C Whisstock
Journal: Genome Res Date: 2000-12 Impact factor: 9.043

Review 2. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.

Authors: G A Silverman; P I Bird; R W Carrell; F C Church; P B Coughlin; P G Gettins; J A Irving; D A Lomas; C J Luke; R W Moyer; P A Pemberton; E Remold-O'Donnell; G S Salvesen; J Travis; J C Whisstock
Journal: J Biol Chem Date: 2001-07-02 Impact factor: 5.157

3. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures.

Authors: Jayanta Debnath; Senthil K Muthuswamy; Joan S Brugge
Journal: Methods Date: 2003-07 Impact factor: 3.608

4. Turnover of thrombomodulin at the cell surface occurs at a similar rate to receptors that are not actively internalized.

Authors: M Chu; C H Bird; M Teasdale; P I Bird
Journal: Thromb Haemost Date: 1998-07 Impact factor: 5.249

5. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.

Authors: S Sheng; J Carey; E A Seftor; L Dias; M J Hendrix; R Sager
Journal: Proc Natl Acad Sci U S A Date: 1996-10-15 Impact factor: 11.205

6. Decline in the expression of the serine proteinase inhibitor maspin is associated with tumour progression in ductal carcinomas of the breast.

Authors: N Maass; M Teffner; F Rösel; R Pawaresch; W Jonat; K Nagasaki; P Rudolph
Journal: J Pathol Date: 2001-10 Impact factor: 7.996

7. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.

Authors: Z Zou; A Anisowicz; M J Hendrix; A Thor; M Neveu; S Sheng; K Rafidi; E Seftor; R Sager
Journal: Science Date: 1994-01-28 Impact factor: 47.728

8. Expression of maspin is up-regulated during the progression of mammary ductal carcinoma.

Authors: Y Umekita; H Yoshida
Journal: Histopathology Date: 2003-06 Impact factor: 5.087

Review 9. Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

Authors: G A Silverman; J C Whisstock; D J Askew; S C Pak; C J Luke; S Cataltepe; J A Irving; P I Bird
Journal: Cell Mol Life Sci Date: 2004-02 Impact factor: 9.261

10. Expression of maspin predicts poor prognosis in breast-cancer patients.

Authors: Yoshihisa Umekita; Yasuyo Ohi; Yoshiatsu Sagara; Hiroki Yoshida
Journal: Int J Cancer Date: 2002-08-01 Impact factor: 7.396

2 in total

1. Maspin is not required for embryonic development or tumour suppression.

Authors: Sonia S Y Teoh; Jessica Vieusseux; Monica Prakash; Susan Berkowicz; Jennii Luu; Catherina H Bird; Ruby H P Law; Carlos Rosado; John T Price; James C Whisstock; Phillip I Bird
Journal: Nat Commun Date: 2014 Impact factor: 14.919

2. Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.

Authors: James C Whisstock; Phillip I Bird; Susan R Berkowicz; Travis J Featherby; Zhengdong Qu; Aminah Giousoh; Natalie A Borg; Julian I Heng
Journal: Mol Autism Date: 2016-03-31 Impact factor: 7.509

2 in total