PURPOSE: To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers. METHODS: Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis. RESULTS: Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin. CONCLUSIONS: In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.
PURPOSE: To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers. METHODS: Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis. RESULTS: Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin. CONCLUSIONS: In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.
Authors: M Jenab; S Salvini; C H van Gils; M Brustad; S Shakya-Shrestha; B Buijsse; H Verhagen; M Touvier; C Biessy; P Wallström; K Bouckaert; E Lund; M Waaseth; N Roswall; A M Joensen; J Linseisen; H Boeing; E Vasilopoulou; V Dilis; S Sieri; C Sacerdote; P Ferrari; J Manjer; S Nilsson; A A Welch; R Travis; M C Boutron-Ruault; M Niravong; H B Bueno-de-Mesquita; Y T van der Schouw; M J Tormo; A Barricarte; E Riboli; S Bingham; N Slimani Journal: Eur J Clin Nutr Date: 2009-11 Impact factor: 4.016
Authors: B Olmedilla; F Granado; S Southon; A J Wright; I Blanco; E Gil-Martinez; H Berg; B Corridan; A M Roussel; M Chopra; D I Thurnham Journal: Br J Nutr Date: 2001-02 Impact factor: 3.718
Authors: Cristina Augood; Astrid Fletcher; Graham Bentham; Usha Chakravarthy; P T V M de Jong; Mati Rahu; Johan Seland; Gisele Soubrane; Laura Tomazzoli; Fotis Topouzis; Jesus Vioque; Ian Young Journal: Ophthalmic Epidemiol Date: 2004-04 Impact factor: 1.648
Authors: A Olsen; J Halkjaer; C H van Gils; B Buijsse; H Verhagen; M Jenab; M C Boutron-Ruault; U Ericson; M C Ocké; P H M Peeters; M Touvier; M Niravong; M Waaseth; G Skeie; K T Khaw; R Travis; P Ferrari; M J Sanchez; A Agudo; K Overvad; J Linseisen; C Weikert; C Sacerdote; A Evangelista; D Zylis; K Tsiotas; J Manjer; B van Guelpen; E Riboli; N Slimani; S Bingham Journal: Eur J Clin Nutr Date: 2009-11 Impact factor: 4.016
Authors: Wael K Al-Delaimy; Anne Linda van Kappel; Pietro Ferrari; Nadia Slimani; Jean-Paul Steghens; Sheila Bingham; Ingegerd Johansson; Peter Wallström; Kim Overvad; Anne Tjønneland; Tim J Key; Ailsa A Welch; H Bas Bueno-de-Mesquita; Petra H M Peeters; Heiner Boeing; Jakob Linseisen; Françoise Clavel-Chapelon; Catherine Guibout; Carmen Navarro; Jose Ramón Quirós; Domenico Palli; Egidio Celentano; Antonia Trichopoulou; Vassiliki Benetou; Rudolf Kaaks; Elio Riboli Journal: Public Health Nutr Date: 2004-09 Impact factor: 4.022
Authors: R Moran; J M Nolan; J Stack; A M O'Halloran; J Feeney; K O Akuffo; R A Kenny; S Beatty Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Valérie Marcil; Emile Levy; Devendra Amre; Alain Bitton; Ana Maria Guilhon de Araújo Sant'Anna; Andrew Szilagy; Daniel Sinnett; Ernest G Seidman Journal: Inflamm Bowel Dis Date: 2019-07-17 Impact factor: 5.325
Authors: Joanne F Dorgan; Seungyoun Jung; Cher M Dallal; Min Zhan; Christina A Stennett; Yuji Zhang; Richard L Eckert; Linda G Snetselaar; Linda Van Horn Journal: Cancer Causes Control Date: 2019-12-11 Impact factor: 2.506
Authors: Alanna J McGrath; Lesley L Hamill; Chris R Cardwell; Claire R Draffin; Charlotte E Neville; Katherine M Appleton; Jane McEneny; Michelle C McKinley; Ian S Young; Jayne V Woodside Journal: Eur J Nutr Date: 2015-06-17 Impact factor: 5.614