Literature DB >> 23097091

The role of promoter hypermethylation in fibroblast activation and fibrogenesis.

Elisabeth M Zeisberg1, Michael Zeisberg.   

Abstract

The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23097091     DOI： 10.1002/path.4120

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  36 in total

Review 1.  TGF-β: the master regulator of fibrosis.

Authors:  Xiao-Ming Meng; David J Nikolic-Paterson; Hui Yao Lan
Journal:  Nat Rev Nephrol       Date:  2016-04-25       Impact factor: 28.314

Review 2.  A perspective on chronic kidney disease progression.

Authors:  Jianyong Zhong; Hai-Chun Yang; Agnes B Fogo
Journal:  Am J Physiol Renal Physiol       Date:  2016-12-14

Review 3.  The evolving relationship of wound healing and tumor stroma.

Authors:  Deshka S Foster; R Ellen Jones; Ryan C Ransom; Michael T Longaker; Jeffrey A Norton
Journal:  JCI Insight       Date:  2018-09-20

Review 4.  Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions.

Authors:  Valeria R Mas; Thu H Le; Daniel G Maluf
Journal:  Transplantation       Date:  2016-01       Impact factor: 4.939

5.  Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis.

Authors:  Björn Tampe; Desiree Tampe; Claudia A Müller; Hikaru Sugimoto; Valerie LeBleu; Xingbo Xu; Gerhard A Müller; Elisabeth M Zeisberg; Raghu Kalluri; Michael Zeisberg
Journal:  J Am Soc Nephrol       Date:  2014-01-30       Impact factor: 10.121

6.  TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis.

Authors:  Clara Dees; Sebastian Pötter; Yun Zhang; Christina Bergmann; Xiang Zhou; Markus Luber; Thomas Wohlfahrt; Emmanuel Karouzakis; Andreas Ramming; Kolja Gelse; Akihiko Yoshimura; Rudolf Jaenisch; Oliver Distler; Georg Schett; Jörg Hw Distler
Journal:  J Clin Invest       Date:  2020-05-01       Impact factor: 14.808

Review 7.  Molecular and Immunological Basis of Tubulo-Interstitial Injury in Lupus Nephritis: a Comprehensive Review.

Authors:  Susan Yung; Tak Mao Chan
Journal:  Clin Rev Allergy Immunol       Date:  2017-04       Impact factor: 8.667

Review 8.  The biology and function of fibroblasts in cancer.

Authors:  Raghu Kalluri
Journal:  Nat Rev Cancer       Date:  2016-08-23       Impact factor: 60.716

9.  Effects of DNA Methylation on Progression to Interstitial Fibrosis and Tubular Atrophy in Renal Allograft Biopsies: A Multi-Omics Approach.

Authors:  S V Bontha; D G Maluf; K J Archer; C I Dumur; M G Dozmorov; A L King; E Akalin; T F Mueller; L Gallon; V R Mas
Journal:  Am J Transplant       Date:  2017-07-08       Impact factor: 8.086

10.  Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution.

Authors:  Eric S White; Alberto R Mantovani
Journal:  J Pathol       Date:  2013-01       Impact factor: 7.996
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.