| Literature DB >> 23096917 |
P F de Aquino1, P C Carvalho, J S da Gama Fischer, A Q L de Souza, J S Viana, S R S Chalub, A D L de Souza, M G C Carvalho.
Abstract
Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patients with gastric carcinomas living in Manaus. In the patients, the samples were taken from tumors and from adjacent non-cancerous mucosa. These samples were screened for EBV DNA by PCR to amplify the 288-bp fragments from the Bam M region. The EBV DNA was detected in 8 of the 10 tumor cases and in none of the 6 control subjects. In the positively identified samples, EBV DNA was detected in five corresponding resection margins. Previous research indicated only a weak association between EBV and gastric cancer. We suggest that EBV should be considered as a risk factor for gastric adenocarcinomas in Manaus.Entities:
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Year: 2012 PMID： 23096917 DOI： 10.4238/2012.October.15.3
Source DB: PubMed Journal: Genet Mol Res ISSN： 1676-5680