Emanuela Fabiola Craparo1, Maria Luisa Bondì. 1. Lab of Biocompatible Polymers, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Università di Palermo bIstituto per lo Studio dei Materiali Nanostrutturati UOS di Palermo-Consiglio Nazionale delle Ricerche, Palermo, Italy.
Abstract
PURPOSE OF REVIEW: The purpose of the present review is to underline the importance of nanoparticulate carriers, such as polymeric nanoparticles, in the future development of safe and effective formulation in the field of immunotherapy against infectious diseases and cancer. RECENT FINDINGS: Polymeric nanoparticles can modulate the immune response, that is, by targeting antigens to dendritic cells that possess a crucial role in initiating immune responses, and might be potentially useful in immunotherapy. SUMMARY: In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of infectious diseases and cancer. Polymeric nanoparticles are particularly adept at facilitating immunotherapeutic approaches because they can be engineered to have different physical properties, encapsulated agents, and surface ligands. Moreover, these systems are administrable for all routes, are capable of being actively taken up by dendritic cells and have shown promising potential in systemic and mucosal immunotherapy. Here, some recent findings on these systems, in their potential applications for infectious and cancer immunotherapy, are reported.
PURPOSE OF REVIEW: The purpose of the present review is to underline the importance of nanoparticulate carriers, such as polymeric nanoparticles, in the future development of safe and effective formulation in the field of immunotherapy against infectious diseases and cancer. RECENT FINDINGS: Polymeric nanoparticles can modulate the immune response, that is, by targeting antigens to dendritic cells that possess a crucial role in initiating immune responses, and might be potentially useful in immunotherapy. SUMMARY: In the last decades, significant progress in research and clinics has been made to offer possible innovative therapeutics for the management of infectious diseases and cancer. Polymeric nanoparticles are particularly adept at facilitating immunotherapeutic approaches because they can be engineered to have different physical properties, encapsulated agents, and surface ligands. Moreover, these systems are administrable for all routes, are capable of being actively taken up by dendritic cells and have shown promising potential in systemic and mucosal immunotherapy. Here, some recent findings on these systems, in their potential applications for infectious and cancer immunotherapy, are reported.
Authors: Reem Ghinnagow; Luis Javier Cruz; Elodie Macho-Fernandez; Christelle Faveeuw; François Trottein Journal: Front Immunol Date: 2017-07-27 Impact factor: 7.561