BACKGROUND: The clinical activity of combination of irinotecan (CPT-11) and nedaplatin (NDP) for recurrent patients with uterine cervical cancer was evaluated retrospectively. METHODS: Intravenous CPT-11 was given at 60 mg/m(2) (days 1, 8, 15), followed by NDP 80 mg/m(2) (day 1), every 4 weeks. RESULTS: According to the medical records, 29 cases have received this regimen since 2000. Median age was 57 years (range, 29-80), and performance status (PS) of the patients was 18 cases with PS 0, 10 cases with PS 1, and 1 case with PS 2, respectively. Clinical stage was as follows: 3 cases of stage Ib1, 2 cases of Ib2, 2 cases of IIa, 10 cases of IIb, 8 cases of IIIb, and 4 cases of IVb. There were 27 cases of squamous cell carcinoma and 2 cases of adenocarcinoma. Concerning hematological toxicity of grade 3 or more, neutropenia, leukopenia, and febrile neutropenia were observed in 79.3 %, 96.6 %, and 13.8 % of cases, respectively. For nonhematological toxicity, nausea, anorexia, joint pain, and confusion were observed in only 1 case, respectively, and as a result, in 7 cases chemotherapy was not completed. Among 26 cases with clinically evaluable lesions, there were 7 complete responses, 3 partial responses, 7 stable disease, and 9 progressive disease; the clinical response rate was 38.5 %. Median progression-free survival was 7 months (range, 0-38 months). CONCLUSION: The combination of CPT-11 and NDP seems to be active for patients with recurrent uterine cervical cancer.
BACKGROUND: The clinical activity of combination of irinotecan (CPT-11) and nedaplatin (NDP) for recurrent patients with uterine cervical cancer was evaluated retrospectively. METHODS: Intravenous CPT-11 was given at 60 mg/m(2) (days 1, 8, 15), followed by NDP 80 mg/m(2) (day 1), every 4 weeks. RESULTS: According to the medical records, 29 cases have received this regimen since 2000. Median age was 57 years (range, 29-80), and performance status (PS) of the patients was 18 cases with PS 0, 10 cases with PS 1, and 1 case with PS 2, respectively. Clinical stage was as follows: 3 cases of stage Ib1, 2 cases of Ib2, 2 cases of IIa, 10 cases of IIb, 8 cases of IIIb, and 4 cases of IVb. There were 27 cases of squamous cell carcinoma and 2 cases of adenocarcinoma. Concerning hematological toxicity of grade 3 or more, neutropenia, leukopenia, and febrile neutropenia were observed in 79.3 %, 96.6 %, and 13.8 % of cases, respectively. For nonhematological toxicity, nausea, anorexia, joint pain, and confusion were observed in only 1 case, respectively, and as a result, in 7 cases chemotherapy was not completed. Among 26 cases with clinically evaluable lesions, there were 7 complete responses, 3 partial responses, 7 stable disease, and 9 progressive disease; the clinical response rate was 38.5 %. Median progression-free survival was 7 months (range, 0-38 months). CONCLUSION: The combination of CPT-11 and NDP seems to be active for patients with recurrent uterine cervical cancer.
Authors: T Sugiyama; M Yakushiji; K Noda; M Ikeda; R Kudoh; A Yajima; Y Tomoda; Y Terashima; S Takeuchi; M Hiura; F Saji; T Takahashi; N Umesaki; S Sato; M Hatae; Y Ohashi Journal: Oncology Date: 2000 Impact factor: 2.935
Authors: T Kato; H Nishimura; M Yakushiji; K Noda; Y Terashima; S Takeuchi; H Takamizawa; M Suzuki; M Arai; M Ota Journal: Gan To Kagaku Ryoho Date: 1992-05
Authors: Jeffrey D Bloss; John A Blessing; Brent C Behrens; Robert S Mannel; Janet S Rader; Anil K Sood; Maurie Markman; Jo Benda Journal: J Clin Oncol Date: 2002-04-01 Impact factor: 44.544
Authors: G A Omura; J A Blessing; L Vaccarello; M L Berman; D L Clarke-Pearson; D G Mutch; B Anderson Journal: J Clin Oncol Date: 1997-01 Impact factor: 44.544
Authors: Harry J Long; Brian N Bundy; Edward C Grendys; Jo Ann Benda; D Scott McMeekin; Joel Sorosky; David S Miller; Lynne A Eaton; James V Fiorica Journal: J Clin Oncol Date: 2005-05-23 Impact factor: 44.544
Authors: K Noda; M Ikeda; M Yakushiji; H Nishimura; Y Terashima; H Sasaki; T Hata; H Kuramoto; K Tanaka; T Takahashi Journal: Gan To Kagaku Ryoho Date: 1992-06
Authors: Bradley J Monk; Michael W Sill; D Scott McMeekin; David E Cohn; Lois M Ramondetta; Cecelia H Boardman; Jo Benda; David Cella Journal: J Clin Oncol Date: 2009-08-31 Impact factor: 44.544
Authors: C Kosmas; N Mylonakis; G Tsakonas; G Vorgias; N Karvounis; N Tsavaris; T Daladimos; N Kalinoglou; N Malamos; T Akrivos; A Karabelis Journal: Br J Cancer Date: 2009-09-08 Impact factor: 7.640
Authors: Kazuma Kobayashi; Naoya Murakami; Kana Takahashi; Koji Inaba; Ryuji Hamamoto; Jun Itami Journal: In Vivo Date: 2019 Sep-Oct Impact factor: 2.155
Authors: Hisham A Abou-Taleb; Masafumi Koshiyama; Noriomi Matsumura; Tsukasa Baba; Ken Yamaguchi; Junzo Hamanishi; Kaoru Abiko; Koji Yamanoi; Ryusuke Murakami; Naoki Horikawa; Ahmed Aa Taha; Sachiko Kitamura; Ikuo Konishi Journal: J Int Med Res Date: 2016-02-01 Impact factor: 1.671