Synthesis and biological activity of organoantimony(III)-containing heteropolytungstates.

Three discrete organoantimony(III)-containing heteropolytungstates [(PhSb(III))(4)(A-α-Ge(IV)W(9)O(34))(2)](12-) (1), [(PhSb(III))(4)(A-α-P(V)W(9)O(34))(2)](10-) (2), and [{2-(Me(2)NCH(2)C(6)H(4))Sb(III)}(3)(B-α-As(III)W(9)O(33))](3-) (3) have been synthesized in one-pot reactions in aqueous medium using the appropriate lacunary heteropolyanion precursor and organoantimony(III) source. Polyanions 1-3 were isolated as hydrated salts, (NH(4))(12)[(PhSb(III))(4)(A-α-Ge(IV)W(9)O(34))(2)]·20H(2)O (1a), Rb(9)Na[(PhSb(III))(4)(A-α-P(V)W(9)O(34))(2)]·20H(2)O (2a), and Rb(3)[{2-(Me(2)NCH(2)C(6)H(4))Sb(III)}(3)(B-α-As(III)W(9)O(33))]·7H(2)O (3a). The compounds 1a-3a were fully characterized in the solid state using infrared (IR) spectroscopy, single-crystal XRD, and thermogravimetric and elemental analyses. The stability of 1-3 in aqueous solution was confirmed by multinuclear NMR ((1)H, (13)C, (31)P, and (183)W) spectroscopy. Preliminary studies on the biological activity of 1-3 showed that all three compounds might act as potent antimicrobial agents.