Literature DB >> 23092440

The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles.

Makhluf J Haddadin1, Wayne E Conrad, Mark J Kurth.   

Abstract

A novel, easy method for the syntheses of richly diversified 2H-indazoles and indazolones, called the Davis-Beirut reaction, and other recent 2H-indazole synthetic routes are briefly reviewed. An update on the biological activity of indazoles is also surveyed.

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Year:  2012        PMID： 23092440     DOI： 10.2174/138955712802762059

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  9 in total

1.  Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction.

Authors:  Jie S Zhu; Jung-Ho Son; Andrew P Teuthorn; Makhluf J Haddadin; Mark J Kurth; Dean J Tantillo
Journal:  J Org Chem       Date:  2017-09-28       Impact factor: 4.354

2.  Photochemical Preparation of 1,2-Dihydro-3 H-indazol-3-ones in Aqueous Solvent at Room Temperature.

Authors:  Jie S Zhu; Niklas Kraemer; Clarabella J Li; Makhluf J Haddadin; Mark J Kurth
Journal:  J Org Chem       Date:  2018-12-06       Impact factor: 4.354

3.  Davis-Beirut Reaction: A Photochemical Brønsted Acid Catalyzed Route to N-Aryl 2H-Indazoles.

Authors:  Niklas Kraemer; Clarabella J Li; Jie S Zhu; Julio M Larach; Ka Yi Tsui; Dean J Tantillo; Makhluf J Haddadin; Mark J Kurth
Journal:  Org Lett       Date:  2019-07-24       Impact factor: 6.005

4.  Accessing Multiple Classes of 2 H-Indazoles: Mechanistic Implications for the Cadogan and Davis-Beirut Reactions.

Authors:  Jie S Zhu; Clarabella J Li; Ka Yi Tsui; Niklas Kraemer; Jung-Ho Son; Makhluf J Haddadin; Dean J Tantillo; Mark J Kurth
Journal:  J Am Chem Soc       Date:  2019-04-04       Impact factor: 15.419

5.  cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339.

Authors:  Gabriel E Büchel; Susanne Kossatz; Ahmad Sadique; Peter Rapta; Michal Zalibera; Lukas Bucinsky; Stanislav Komorovsky; Joshua Telser; Jörg Eppinger; Thomas Reiner; Vladimir B Arion
Journal:  Dalton Trans       Date:  2017-09-12       Impact factor: 4.390

6.  Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media.

Authors:  Hui-Jun Nie; An-Di Guo; Hai-Xia Lin; Xiao-Hua Chen
Journal:  RSC Adv       Date:  2019-04-30       Impact factor: 4.036

7.  Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles.

Authors:  Mei-Huey Lin; Kung-Yu Liang; Chang-Hsien Tsai; Yu-Chun Chen; Hung-Chang Hsiao; Yi-Syuan Li; Chung-Hao Chen; Hau-Chun Wu
Journal:  Molecules       Date:  2016-02-19       Impact factor: 4.411

8.  Rhodium(III)-catalyzed indazole synthesis by C-H bond functionalization and cyclative capture.

Authors:  Yajing Lian; Robert G Bergman; Luke D Lavis; Jonathan A Ellman
Journal:  J Am Chem Soc       Date:  2013-05-03       Impact factor: 15.419

9.  Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles.

Authors:  Kelli M Farber; Makhluf J Haddadin; Mark J Kurth
Journal:  J Org Chem       Date:  2014-07-23       Impact factor: 4.354
  9 in total

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