Literature DB >> 23092429

Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac.

Suresh Awale1, Jun-ya Ueda, Sirivan Athikomkulchai, Dya Fita Dibwe, Sherif Abdelhamed, Satoru Yokoyama, Ikuo Saiki, Ryuta Miyatake.   

Abstract

Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23092429     DOI： 10.1021/np300596c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  2 in total

Review 1.  Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation.

Authors:  Juriyati Jalil; Ali Attiq; Chiew Chia Hui; Lui Jin Yao; Nurul Aimi Zakaria
Journal:  Inflammopharmacology       Date:  2020-07-02       Impact factor: 4.473

2.  Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells.

Authors:  Benjamin E Alexander; Sijia Sun; Matthew J Palframan; Gabriele Kociok-Köhn; Dya Fita Dibwe; Shiro Watanabe; Lorenzo Caggiano; Suresh Awale; Simon E Lewis
Journal:  ChemMedChem       Date:  2019-12-10       Impact factor: 3.466
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.