Literature DB >> 23090640

Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes.

Melissa L McIntosh1, Michael R Naffziger, Bradley O Ashburn, Lev N Zakharov, Rich G Carter.   

Abstract

The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.

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Year:  2012        PMID： 23090640     DOI： 10.1039/c2ob26267c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

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2.  Ruthenium-catalyzed cycloadditions of 1-haloalkynes with nitrile oxides and organic azides: synthesis of 4-haloisoxazoles and 5-halotriazoles.

Authors:  James S Oakdale; Rakesh K Sit; Valery V Fokin
Journal:  Chemistry       Date:  2014-07-24       Impact factor: 5.236

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Journal:  Int J Mol Sci       Date:  2020-12-09       Impact factor: 5.923
  3 in total

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