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Literature DB >> 23090536

Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?

Abstract

Changes in maternal physiology during pregnancy can alter the absorption, distribution, and clearance of many drugs. When presented with a clinical situation in which it does not appear that a prescribed drug is working, clinicians must either change drugs or increase the dose of the current drug to achieve the desired clinical effect. A case highlighting antihypertensive medication in pregnancy and the effect of changed drug-metabolizing enzymes is presented. Understanding pregnancy's effect on drug-metabolizing enzymes, transporters, and receptors can help clinicians make individualized pharmacotherapeutic decisions for patients. Pharmacogenetics potentially can aid clinicians in treating pregnant women in the future as more data are generated and individualized therapeutic models are constructed.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 23090536 PMCID： PMC3555224 DOI： 10.1097/aog.0b013e3182698538

Source DB: PubMed Journal: Obstet Gynecol ISSN： 0029-7844 Impact factor: 7.661

27 in total

Review 1. Drugs in pregnancy. Pharmacokinetics in pregnancy.

Authors: M Dawes; P J Chowienczyk
Journal: Best Pract Res Clin Obstet Gynaecol Date: 2001-12 Impact factor: 5.237

Review 2. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.

Authors: Magnus Ingelman-Sundberg
Journal: Trends Pharmacol Sci Date: 2004-04 Impact factor: 14.819

3. VKORC1, CYP2C9 and CYP4F2 genetic-based algorithm for warfarin dosing: an Italian retrospective study.

Authors: Carlo-Federico Zambon; Vittorio Pengo; Roberto Padrini; Daniela Basso; Stefania Schiavon; Paola Fogar; Alessandra Nisi; Anna Chiara Frigo; Stefania Moz; Michela Pelloso; Mario Plebani
Journal: Pharmacogenomics Date: 2011-01 Impact factor: 2.533

4. H1N1 influenza in pregnancy: cause for concern.

Authors: Erin Saleeby; Jocelyn Chapman; Jessica Morse; Allison Bryant
Journal: Obstet Gynecol Date: 2009-10 Impact factor: 7.661

5. Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies.

Authors: M A Andrew; T R Easterling; D B Carr; D Shen; M L Buchanan; T Rutherford; R Bennett; P Vicini; M F Hebert
Journal: Clin Pharmacol Ther Date: 2007-02-28 Impact factor: 6.875

6. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism.

Authors: Erik K Alexander; Ellen Marqusee; Jennifer Lawrence; Petr Jarolim; George A Fischer; P Reed Larsen
Journal: N Engl J Med Date: 2004-07-15 Impact factor: 91.245

7. Pregnancy-induced increase in metoprolol metabolism.

Authors: S Högstedt; B Lindberg; D R Peng; C G Regårdh; A Rane
Journal: Clin Pharmacol Ther Date: 1985-06 Impact factor: 6.875

8. Clonidine pharmacokinetics in pregnancy.

Authors: M L Buchanan; T R Easterling; D B Carr; D D Shen; L J Risler; W L Nelson; D R Mattison; M F Hebert
Journal: Drug Metab Dispos Date: 2008-12-30 Impact factor: 3.922

9. Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.

Authors: M F Hebert; T R Easterling; B Kirby; D B Carr; M L Buchanan; T Rutherford; K E Thummel; D P Fishbein; J D Unadkat
Journal: Clin Pharmacol Ther Date: 2008-02-20 Impact factor: 6.903

10. Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.

Authors: M F Hebert; X Ma; S B Naraharisetti; K M Krudys; J G Umans; G D V Hankins; S N Caritis; M Miodovnik; D R Mattison; J D Unadkat; E J Kelly; D Blough; C Cobelli; M S Ahmed; W R Snodgrass; D B Carr; T R Easterling; P Vicini
Journal: Clin Pharmacol Ther Date: 2009-03-18 Impact factor: 6.903

5 in total

Pharmacogenetics and other reasons why drugs can fail in pregnancy: higher dose or different drug?

Review 1. Drugs in pregnancy. Pharmacokinetics in pregnancy.

Review 2. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future.

3. VKORC1, CYP2C9 and CYP4F2 genetic-based algorithm for warfarin dosing: an Italian retrospective study.

4. H1N1 influenza in pregnancy: cause for concern.

5. Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies.

6. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism.

7. Pregnancy-induced increase in metoprolol metabolism.

8. Clonidine pharmacokinetics in pregnancy.

9. Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.

10. Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.

1. Use of Antipsychotics During Pregnancy: Pregnant Women Get Sick-Sick Women Get Pregnant.

Review 2. Pharmacogenetics and individualizing drug treatment during pregnancy.

Review 3. Use of medication for cardiovascular disease during pregnancy.

4. Pharmacogenomic Testing In Pediatrics: Navigating The Ethical, Social, And Legal Challenges.

Review 5. Short-term tocolytics for preterm delivery - current perspectives.