Literature DB >> 23090241

Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083.

Fa-Guang Zhang1, Xiao-Yan Zhu, Shen Li, Jing Nie, Jun-An Ma.   

Abstract

A highly efficient, organocatalytic, enantioselective Strecker reaction of cyclic N-acyl ketimines was developed for the preparation of enantioenriched cyclic α-amino nitriles with a quaternary carbon stereocentre and anti-HIV drug DPC 083.

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Year:  2012        PMID: 23090241     DOI: 10.1039/c2cc36307k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

1.  Strategies for the Catalytic Enantioselective Synthesis of α-Trifluoromethyl Amines.

Authors:  Chibueze I Onyeagusi; Steven J Malcolmson
Journal:  ACS Catal       Date:  2020-10-12       Impact factor: 13.084

2.  A bifunctional iminophosphorane squaramide catalyzed enantioselective synthesis of hydroquinazolines via intramolecular aza-Michael reaction to α,β-unsaturated esters.

Authors:  Guanglong Su; Connor J Thomson; Ken Yamazaki; Daniel Rozsar; Kirsten E Christensen; Trevor A Hamlin; Darren J Dixon
Journal:  Chem Sci       Date:  2021-03-18       Impact factor: 9.825

Review 3.  Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients.

Authors:  Ángel Cores; José Clerigué; Emmanuel Orocio-Rodríguez; J Carlos Menéndez
Journal:  Pharmaceuticals (Basel)       Date:  2022-08-17
  3 in total

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