| Literature DB >> 23089579 |
Kunkun Zhu1, Ting Ye, Jinjin Liu, Zheng Peng, Shasha Xu, Jieqiong Lei, Hongbing Deng, Bin Li.
Abstract
Lysozyme (Ly) and sodium carboxymethyl cellulose (CMC) were used to fabricate nanogels by a convenient method without using any chemical treatment except simple heating to achieve the denaturation temperature of Ly. The prepared nanogels were characterized by dynamic laser scattering (DLS), rheological analysis, transmission electron microscopy (TEM), field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS). The nanogels are of spherical shape with average hydrodynamic diameter of 241 nm and the swelling ratio of nanogels is about 5. Then 5-fluorouracil was used as a model drug to investigate the entrapment efficiency and release ability in nanogels. It turned out to be that the release in simulated gastric fluid (SGF) was more slowly compared with that in simulated intestinal fluid (SIF), which could protect the 5-Fu in stomach and ensure it released in intestines.Entities:
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Year: 2012 PMID： 23089579 DOI： 10.1016/j.ijpharm.2012.10.022
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875