BACKGROUND: When induction chemotherapy (IC) is used prior to chemoradiotherapy (CRT) in head and neck cancer (HNC), functional imaging (FI) may inform adaptation of treatment plans with the aim of optimising outcomes. Understanding the impact of IC on FI parameters is, therefore, essential. PURPOSE: To prospectively evaluate the feasibility of acquiring serial FI ((18)F-FDG-PET, diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI) and its role in defining individualised treatment regimens following IC in HNC. METHODS AND MATERIALS: Ten patients with stage III and IV HNC underwent conventional (CT and MRI) and functional (DW, DCE-MRI and (18)F-FDG-PET/CT) imaging at baseline and following two cycles of IC prior to definitive CRT. RESULTS: One patient withdrew due to claustrophobia. Seven out of nine patients had a complete metabolic response to IC on (18)F-FDG-PET imaging. DCE-MRI showed a significant fall in transfer constant (K(trans)) (0.209 vs 0.129 min(-1)P<0.01) and integrated area under gadolinium curve at 60s (IAUGC6O) (18.4 vs 11.9 mmol/min, P<0.01) and DW-MRI a rise in ADC (0.89 vs 1.06 × 10(-3) mm(2)/s, P<0.01) following IC. CONCLUSIONS: Acquiring FI sequences is feasible in HNC. There are marked changes in FI parameters following IC which may guide adaptation of individualised treatment regimens.
BACKGROUND: When induction chemotherapy (IC) is used prior to chemoradiotherapy (CRT) in head and neck cancer (HNC), functional imaging (FI) may inform adaptation of treatment plans with the aim of optimising outcomes. Understanding the impact of IC on FI parameters is, therefore, essential. PURPOSE: To prospectively evaluate the feasibility of acquiring serial FI ((18)F-FDG-PET, diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI) and its role in defining individualised treatment regimens following IC in HNC. METHODS AND MATERIALS: Ten patients with stage III and IV HNC underwent conventional (CT and MRI) and functional (DW, DCE-MRI and (18)F-FDG-PET/CT) imaging at baseline and following two cycles of IC prior to definitive CRT. RESULTS: One patient withdrew due to claustrophobia. Seven out of nine patients had a complete metabolic response to IC on (18)F-FDG-PET imaging. DCE-MRI showed a significant fall in transfer constant (K(trans)) (0.209 vs 0.129 min(-1)P<0.01) and integrated area under gadolinium curve at 60s (IAUGC6O) (18.4 vs 11.9 mmol/min, P<0.01) and DW-MRI a rise in ADC (0.89 vs 1.06 × 10(-3) mm(2)/s, P<0.01) following IC. CONCLUSIONS: Acquiring FI sequences is feasible in HNC. There are marked changes in FI parameters following IC which may guide adaptation of individualised treatment regimens.
Authors: Marco Borri; Maria A Schmidt; Ceri Powell; Dow-Mu Koh; Angela M Riddell; Mike Partridge; Shreerang A Bhide; Christopher M Nutting; Kevin J Harrington; Katie L Newbold; Martin O Leach Journal: PLoS One Date: 2015-09-23 Impact factor: 3.240
Authors: Matthias Gawlitza; Sandra Purz; Klaus Kubiessa; Andreas Boehm; Henryk Barthel; Regine Kluge; Thomas Kahn; Osama Sabri; Patrick Stumpp Journal: PLoS One Date: 2015-08-13 Impact factor: 3.240
Authors: Liam Welsh; Rafal Panek; Dualta McQuaid; Alex Dunlop; Maria Schmidt; Angela Riddell; Dow-Mu Koh; Simon Doran; Iain Murray; Yong Du; Sue Chua; Vibeke Hansen; Kee H Wong; Jamie Dean; Sarah Gulliford; Shreerang Bhide; Martin O Leach; Christopher Nutting; Kevin Harrington; Kate Newbold Journal: Radiat Oncol Date: 2015-05-15 Impact factor: 3.481
Authors: Arthur Varoquaux; Olivier Rager; Antoine Poncet; Bénédicte M A Delattre; Osman Ratib; Christoph D Becker; Pavel Dulguerov; Nicolas Dulguerov; Habib Zaidi; Minerva Becker Journal: Eur J Nucl Med Mol Imaging Date: 2013-10-10 Impact factor: 9.236