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Literature DB >> 2308900

Microbial metabolism studies of the antimalarial drug arteether.

Abstract

Microbial metabolism studies of the antimalarial drug arteether (1) have shown that arteether is metabolized by a number of microorganisms. Large-scale fermentation with Aspergillus niger (ATCC 10549) and Nocardia corallina (ATCC 19070) have resulted in the isolation of four microbial metabolites which have been characterized using two-dimensional nuclear magnetic resonance (2D-NMR) techniques. These metabolites have been identified as "AEM1" (2), 3 alpha-hydroxydeoxyarteether (3), 3 alpha-hydroxydeoxydihydroartemisinin (4), and deoxydihydroartemisinin (5).

Entities: Chemical Species

Mesh：

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Year: 1990 PMID： 2308900 DOI： 10.1023/a:1015845306124

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

10 in total

1. Microbial models of mammalian metabolism.

Authors: R V Smith; J P Rosazza
Journal: J Pharm Sci Date: 1975-11 Impact factor: 3.534

2. Microbial metabolism studies of the antimalarial sesquiterpene artemisinin.

Authors: I S Lee; H N elSohly; E M Croom; C D Hufford
Journal: J Nat Prod Date: 1989 Mar-Apr Impact factor: 4.050

Review 3. Microbial models for drug metabolism.

Authors: J P Rosazza; R V Smith
Journal: Adv Appl Microbiol Date: 1979 Impact factor: 5.086

4. Metabolism and pharmacokinetics of qinghaosu and its derivatives. China Cooperative Research Group on qinghaosu and its derivatives as antimalarials.

Authors:
Journal: J Tradit Chin Med Date: 1982-03 Impact factor: 0.848

5. [Studies on the physiological disposition of Qing-Hao-Sou. I. Biotransformation of Qing-Hao-Sou after oral medication in human (author's transl)].

Authors: D Y Zhu; B S Huang; Z L Chen; M L Yin
Journal: Yao Xue Xue Bao Date: 1980-08

6. Thermospray mass spectroscopy/high performance liquid chromatographic identification of the metabolites formed from arteether using a rat liver microsome preparation.

Authors: J K Baker; R H Yarber; C D Hufford; I S Lee; H N ElSohly; J D McChesney
Journal: Biomed Environ Mass Spectrom Date: 1989-05

7. Microbial metabolism of bornaprine, 3-(diethylamino)propyl 2-phenylbicyclo[2.2.1]heptane-2-carboxylate.

Authors: S A Elmarakby; A M Clark; J K Baker; C D Hufford
Journal: J Pharm Sci Date: 1986-06 Impact factor: 3.534

8. Arteether, a new antimalarial drug: synthesis and antimalarial properties.

Authors: A Brossi; B Venugopalan; L Dominguez Gerpe; H J Yeh; J L Flippen-Anderson; P Buchs; X D Luo; W Milhous; W Peters
Journal: J Med Chem Date: 1988-03 Impact factor: 7.446

Review 9. The use of microorganisms for the study of drug metabolism.

Authors: A M Clark; J D McChesney; C D Hufford
Journal: Med Res Rev Date: 1985 Apr-Jun Impact factor: 12.944

Review 10. Qinghaosu (artemisinin): an antimalarial drug from China.

Authors: D L Klayman
Journal: Science Date: 1985-05-31 Impact factor: 47.728

10 in total

5 in total

1. Structure elucidation and thermospray high-performance liquid chromatography/mass spectroscopy (HPLC/MS) of the microbial and mammalian metabolites of the antimalarial arteether.

Authors: C D Hufford; I S Lee; H N ElSohly; H T Chi; J K Baker
Journal: Pharm Res Date: 1990-09 Impact factor: 4.200