BACKGROUND: There is concern about a possible association between influenza A(H1N1)pdm09 vaccination and narcolepsy. In this study, we assessed the incidence and incidence rate of narcolepsy in the South Korean population before and after the implementation of an A(H1N1)pdm09 vaccination campaign to see if vaccination led to a change in the occurrence of narcolepsy. METHODS: We conducted an ecological study, comparing incident cases and incidence rates for newly diagnosed narcolepsy case-patients in South Korea, between July 2006 and June 2011. We used data from the Health Insurance Review Agency and Korea Centers for Disease Control and Prevention, which have limited information on case ascertainment. During vaccination campaign period, South Korea used non-adjuvanted and MF59-adjuvanted A(H1N1)pdm09 vaccines. RESULTS: Generally, incidence rate was highest in prepandemic period. No trend toward increase in the incidence of narcolepsy after pandemic period was found. Observation of incidence by season did not suggest any time pattern for occurrence of narcolepsy. CONCLUSION: No increase in cases or incidence rate for narcolepsy during the A(H1N1)pdm09 vaccination campaign was found in South Korea. Our data do not support the use of MF59-adjuvanted or non-adjuvanted A(H1N1)pdm09 vaccine as a trigger for narcolepsy on a population level.
BACKGROUND: There is concern about a possible association between influenza A(H1N1)pdm09 vaccination and narcolepsy. In this study, we assessed the incidence and incidence rate of narcolepsy in the South Korean population before and after the implementation of an A(H1N1)pdm09 vaccination campaign to see if vaccination led to a change in the occurrence of narcolepsy. METHODS: We conducted an ecological study, comparing incident cases and incidence rates for newly diagnosed narcolepsy case-patients in South Korea, between July 2006 and June 2011. We used data from the Health Insurance Review Agency and Korea Centers for Disease Control and Prevention, which have limited information on case ascertainment. During vaccination campaign period, South Korea used non-adjuvanted and MF59-adjuvanted A(H1N1)pdm09 vaccines. RESULTS: Generally, incidence rate was highest in prepandemic period. No trend toward increase in the incidence of narcolepsy after pandemic period was found. Observation of incidence by season did not suggest any time pattern for occurrence of narcolepsy. CONCLUSION: No increase in cases or incidence rate for narcolepsy during the A(H1N1)pdm09 vaccination campaign was found in South Korea. Our data do not support the use of MF59-adjuvanted or non-adjuvanted A(H1N1)pdm09 vaccine as a trigger for narcolepsy on a population level.
Authors: Anne Marie Winstone; Lesley Stellitano; Christopher Verity; Nick Andrews; Elizabeth Miller; Julia Stowe; John Shneerson Journal: Dev Med Child Neurol Date: 2014-07-10 Impact factor: 5.449
Authors: Outi Vaarala; Arja Vuorela; Markku Partinen; Marc Baumann; Tobias L Freitag; Seppo Meri; Päivi Saavalainen; Matti Jauhiainen; Rabah Soliymani; Turkka Kirjavainen; Päivi Olsen; Outi Saarenpää-Heikkilä; Juha Rouvinen; Merja Roivainen; Hanna Nohynek; Jukka Jokinen; Ilkka Julkunen; Terhi Kilpi Journal: PLoS One Date: 2014-12-15 Impact factor: 3.240
Authors: Shaden Q Qasrawi; Ali M Albarrak; Adel S Alharbi; Samar Nashwan; Aljohara S Almeneessier; Seithikurippu R Pandi-Perumal; Muslim M Alsaadi; Ahmed S BaHammam Journal: Saudi Med J Date: 2017-12 Impact factor: 1.484