Literature DB >> 23088773

Synthesis of two unnatural oxygenated aaptaminoids.

Giorgio Abbiati1, Arjana Doda, Monica Dell'Acqua, Valentina Pirovano, Diego Facoetti, Silvia Rizzato, Elisabetta Rossi.   

Abstract

Two unprecedented oxygenated aaptaminoids have been synthesized starting from cheap and easily available 2,3-dihydroxybenzoic acid with the satisfactory overall yields of 31% and 34%. The key step of the procedure is the divergent thermic 5-exodig vs base-promoted 6-endodig cyclization of a 5-alkynylquinolinone derivative.

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Year:  2012        PMID: 23088773     DOI: 10.1021/jo3020598

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Aaptamine derivatives with antifungal and anti-HIV-1 activities from the South China Sea sponge Aaptos aaptos.

Authors:  Hao-Bing Yu; Fan Yang; Fan Sun; Jing Li; Wei-Hua Jiao; Jian-Hong Gan; Wen-Zhen Hu; Hou-Wen Lin
Journal:  Mar Drugs       Date:  2014-12-16       Impact factor: 5.118

2.  Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress.

Authors:  Chih-Fung Wu; Man-Gang Lee; Mohamed El-Shazly; Kuei-Hung Lai; Seng-Chung Ke; Chiang-Wen Su; Shou-Ping Shih; Ping-Jyun Sung; Ming-Chang Hong; Zhi-Hong Wen; Mei-Chin Lu
Journal:  Mar Drugs       Date:  2018-01-09       Impact factor: 5.118

  2 in total

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