Literature DB >> 23087716

The role of the immune system in the physiopathology of osteoporosis.

Valentina Cagnetta1, Vittorio Patella.   

Abstract

The close anatomical relationship between the immune system, estrogen deficiency and bone loss has been recognized for centuries but the existence of a functional relationship has emerged only recently. The role of the immune system in the development of senile osteoporosis, which arises primarily through the effects of estrogen deficiency and secondary hyperparathyroidism, is slowly being unraveled. This review focuses the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and their activity. The under standing of the interplay of inflammation and osteoclast can lead to the development of new drugs for prevention and treatment of bone loss.

Entities:  

Keywords:  B cells; T cells; cytokines; immune system; osteoclast; osteoporosis

Year:  2012        PMID： 23087716      PMCID： PMC3476525     

Source DB:  PubMed          Journal:  Clin Cases Miner Bone Metab        ISSN： 1724-8914


  50 in total

1.  Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.

Authors:  Simone Cenci; Gianluca Toraldo; M Neale Weitzmann; Cristiana Roggia; Yuhao Gao; Wei Ping Qian; Oscar Sierra; Roberto Pacifici
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-15       Impact factor: 11.205

Review 2.  Transcriptional regulation of the MHC class II antigen presentation pathway.

Authors:  Jeremy M Boss; Peter E Jensen
Journal:  Curr Opin Immunol       Date:  2003-02       Impact factor: 7.486

3.  Role of RANK ligand in mediating increased bone resorption in early postmenopausal women.

Authors:  Guitty Eghbali-Fatourechi; Sundeep Khosla; Arunik Sanyal; William J Boyle; David L Lacey; B Lawrence Riggs
Journal:  J Clin Invest       Date:  2003-04       Impact factor: 14.808

4.  An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency.

Authors:  Michaela Robbie Ryan; Rebecca Shepherd; Jennifer K Leavey; Yuhao Gao; Francesco Grassi; Frederick J Schnell; Wei-Ping Qian; Gilbert J Kersh; M Neale Weitzmann; Roberto Pacifici
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-02       Impact factor: 11.205

Review 5.  Minireview: the OPG/RANKL/RANK system.

Authors:  S Khosla
Journal:  Endocrinology       Date:  2001-12       Impact factor: 4.736

6.  Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo.

Authors:  C Roggia; Y Gao; S Cenci; M N Weitzmann; G Toraldo; G Isaia; R Pacifici
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-20       Impact factor: 11.205

7.  IL-1 mediates TNF-induced osteoclastogenesis.

Authors:  Shi Wei; Hideki Kitaura; Ping Zhou; F Patrick Ross; Steven L Teitelbaum
Journal:  J Clin Invest       Date:  2005-02       Impact factor: 14.808

8.  Role of TNF-alpha producing T-cells in bone loss induced by estrogen deficiency.

Authors:  C Roggia; C Tamone; S Cenci; R Pacifici; G C Isaia
Journal:  Minerva Med       Date:  2004-04       Impact factor: 4.806

9.  IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells.

Authors:  Gianluca Toraldo; Cristiana Roggia; Wei-Ping Qian; Roberto Pacifici; M Neale Weitzmann
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-18       Impact factor: 11.205

10.  Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.

Authors:  Kojiro Sato; Ayako Suematsu; Kazuo Okamoto; Akira Yamaguchi; Yasuyuki Morishita; Yuho Kadono; Sakae Tanaka; Tatsuhiko Kodama; Shizuo Akira; Yoichiro Iwakura; Daniel J Cua; Hiroshi Takayanagi
Journal:  J Exp Med       Date:  2006-11-06       Impact factor: 14.307
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  7 in total

1.  Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis.

Authors:  Ying-Qi Liu; Yong Liu; Qiang Zhang; Tao Xiao; Hong-Wen Deng
Journal:  Calcif Tissue Int       Date:  2021-03-19       Impact factor: 4.333

Review 2.  Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis.

Authors:  Laura Gambari; Francesco Grassi; Livia Roseti; Brunella Grigolo; Giovanna Desando
Journal:  Int J Mol Sci       Date:  2020-08-20       Impact factor: 5.923

3.  Panax Notoginseng Saponins Prevent Bone Loss by Promoting Angiogenesis in an Osteoporotic Mouse Model.

Authors:  Hao Hu; Yan Chen; Zhiyuan Zou; Liangping Li; Fuxin Wei; Chun Liu; Zemin Ling; Xuenong Zou
Journal:  Biomed Res Int       Date:  2020-12-14       Impact factor: 3.411

Review 4.  Th17 and Treg cells in bone related diseases.

Authors:  Min Wang; Tian Tian; Shuang Yu; Na He; Daoxin Ma
Journal:  Clin Dev Immunol       Date:  2013-09-25

5.  A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia.

Authors:  Roozbeh Khosravi; Katharine L Sodek; Wan-Peng Xu; Manish V Bais; Debashree Saxena; Michael Faibish; Philip C Trackman
Journal:  PLoS One       Date:  2014-06-27       Impact factor: 3.240

6.  Effects of Salvia miltiorrhiza extract with supplemental liquefied calcium on osteoporosis in calcium-deficient ovariectomized mice.

Authors:  Bongkyun Park; Hae Seong Song; Jeong Eun Kwon; Se Min Cho; Seon-A Jang; Mi Yeon Kim; Se Chan Kang
Journal:  BMC Complement Altern Med       Date:  2017-12-20       Impact factor: 3.659

7.  Comprehensive Analysis of the Genetic and Epigenetic Mechanisms of Osteoporosis and Bone Mineral Density.

Authors:  Hui Dong; Wenyang Zhou; Pingping Wang; Enjun Zuo; Xiaoxia Ying; Songling Chai; Tao Fei; Laidi Jin; Chen Chen; Guowu Ma; Huiying Liu
Journal:  Front Cell Dev Biol       Date:  2020-03-25
  7 in total

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