Literature DB >> 23087426

IL-4 in the brain: a cytokine to remember.

Sachin P Gadani1, James C Cronk, Geoffrey T Norris, Jonathan Kipnis.   

Abstract

IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23087426      PMCID： PMC3481177          DOI： 10.4049/jimmunol.1202246

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  100 in total

Review 1.  Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium.

Authors:  Melissa L Bondy; Michael E Scheurer; Beatrice Malmer; Jill S Barnholtz-Sloan; Faith G Davis; Dora Il'yasova; Carol Kruchko; Bridget J McCarthy; Preetha Rajaraman; Judith A Schwartzbaum; Siegal Sadetzki; Brigitte Schlehofer; Tarik Tihan; Joseph L Wiemels; Margaret Wrensch; Patricia A Buffler
Journal:  Cancer       Date:  2008-10-01       Impact factor: 6.860

Review 2.  Isolation, characterization, and use of stem cells from the CNS.

Authors:  F H Gage; J Ray; L J Fisher
Journal:  Annu Rev Neurosci       Date:  1995       Impact factor: 12.449

3.  Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen.

Authors:  W Debinski; D M Gibo
Journal:  Mol Med       Date:  2000-05       Impact factor: 6.354

4.  Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice.

Authors:  Ashley M Fenn; Christopher J Henry; Yan Huang; Allison Dugan; Jonathan P Godbout
Journal:  Brain Behav Immun       Date:  2011-10-17       Impact factor: 7.217

5.  Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat.

Authors:  F O Maher; Yvonne Nolan; Marina A Lynch
Journal:  Neurobiol Aging       Date:  2005-05       Impact factor: 4.673

6.  IFN-gamma and IL-4 differentially shape metabolic responses and neuroprotective phenotype of astrocytes.

Authors:  Sanjay K Garg; Jonathan Kipnis; Ruma Banerjee
Journal:  J Neurochem       Date:  2009-01-07       Impact factor: 5.372

7.  IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.

Authors:  Vasilena Gocheva; Hao-Wei Wang; Bedrick B Gadea; Tanaya Shree; Karen E Hunter; Alfred L Garfall; Tara Berman; Johanna A Joyce
Journal:  Genes Dev       Date:  2010-01-15       Impact factor: 11.361

8.  Recombinant human interleukin 4 has antiproliferative activity on human tumor cell lines derived from epithelial and nonepithelial histologies.

Authors:  M S Topp; C A Papadimitriou; F Eitelbach; M Koenigsmann; E Oelmann; B Koehler; D Oberberg; B Reufi; H Stein; E Thiel
Journal:  Cancer Res       Date:  1995-05-15       Impact factor: 12.701

9.  Rapid and selective induction of BDNF expression in the hippocampus during contextual learning.

Authors:  J Hall; K L Thomas; B J Everitt
Journal:  Nat Neurosci       Date:  2000-06       Impact factor: 24.884

10.  AGEMAP: a gene expression database for aging in mice.

Authors:  Jacob M Zahn; Suresh Poosala; Art B Owen; Donald K Ingram; Ana Lustig; Arnell Carter; Ashani T Weeraratna; Dennis D Taub; Myriam Gorospe; Krystyna Mazan-Mamczarz; Edward G Lakatta; Kenneth R Boheler; Xiangru Xu; Mark P Mattson; Geppino Falco; Minoru S H Ko; David Schlessinger; Jeffrey Firman; Sarah K Kummerfeld; William H Wood; Alan B Zonderman; Stuart K Kim; Kevin G Becker
Journal:  PLoS Genet       Date:  2007-10-02       Impact factor: 5.917
View more
  171 in total

1.  Adipocytokines leptin and adiponectin function as mast cell activity modulators.

Authors:  Paulina Żelechowska; Ewa Brzezińska-Błaszczyk; Magdalena Wiktorska; Sylwia Różalska; Sebastian Wawrocki; Elżbieta Kozłowska; Justyna Agier
Journal:  Immunology       Date:  2019-07-10       Impact factor: 7.397

2.  Neuroinflammation in psychiatric disorders: An introductory primer.

Authors:  Geoffrey A Dunn; Jennifer M Loftis; Elinor L Sullivan
Journal:  Pharmacol Biochem Behav       Date:  2020-07-01       Impact factor: 3.533

Review 3.  (Putative) sex differences in neuroimmune modulation of memory.

Authors:  Natalie C Tronson; Katie M Collette
Journal:  J Neurosci Res       Date:  2017-01-02       Impact factor: 4.164

4.  Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.

Authors:  Matthew G Frank; Laura K Fonken; Samuel D Dolzani; Jessica L Annis; Philip H Siebler; Dominic Schmidt; Linda R Watkins; Steven F Maier; Christopher A Lowry
Journal:  Brain Behav Immun       Date:  2018-05-26       Impact factor: 7.217

5.  T helper 2 differentiation is necessary for development of lymphedema.

Authors:  Catherine L Ly; Gabriela D García Nores; Raghu P Kataru; Babak J Mehrara
Journal:  Transl Res       Date:  2018-12-21       Impact factor: 7.012

6.  Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling.

Authors:  William H Walker; O Hecmarie Meléndez-Fernández; Jordan L Pascoe; Ning Zhang; A Courtney DeVries
Journal:  Brain Behav Immun       Date:  2020-07-29       Impact factor: 7.217

7.  Identifying cytokine predictors of cognitive functioning in breast cancer survivors up to 10 years post chemotherapy using machine learning.

Authors:  Ashley M Henneghan; Oxana Palesh; Michelle Harrison; Shelli R Kesler
Journal:  J Neuroimmunol       Date:  2018-04-19       Impact factor: 3.478

8.  Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia.

Authors:  Han Kyu Lee; Sehwon Koh; Donald C Lo; Douglas A Marchuk
Journal:  FEBS J       Date:  2018-05-24       Impact factor: 5.542

9.  The role of the immune system during regeneration of the central nervous system.

Authors:  K Z Sabin; K Echeverri
Journal:  J Immunol Regen Med       Date:  2019-11-05

10.  In vitro effects of azide-containing human CRP isoforms and oxLDL on U937-derived macrophage production of atherosclerosis-related cytokines.

Authors:  Dania Jundi; Imtissal Krayem; Samer Bazzi; Marc Karam
Journal:  Exp Ther Med       Date:  2020-09-04       Impact factor: 2.447
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.