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Literature DB >> 23087121

Genome sequence of a natural reassortant H5N2 avian influenza virus from domestic mallard ducks in eastern China.

Min Gu¹, Junqing Huang, Yuxin Chen, Jian Chen, Xiaoquan Wang, Xiaowen Liu, Xiufan Liu.

Abstract

Here, we report the genomic sequence of a Chinese reassortant H5N2 avian influenza virus which possessed the polybasic motif PLREKRRK-R/GL at the hemagglutinin cleavage site. Phylogenetic analysis showed that all eight genes were of the Eurasian lineage, five of which were highly homologous to the endemic clade 2.3.4 H5N1 viruses and their H5N5 reassortant descendants. These data suggested that novel multisubtypic NA reassortants bearing the H5N1 backbone could be generated through genetic reassortment in H5N1 circulating regions, which will help in understanding the evolution and segment reassortment mechanism of H5 subtype avian influenza viruses.

Entities: Chemical Species

Mesh：

Substances：
DNA, Viral

Year: 2012 PMID： 23087121 PMCID： PMC3486508 DOI： 10.1128/JVI.02315-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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