Literature DB >> 23085876

The UCSF-FDA TransPortal: a public drug transporter database.

K M Morrissey1, C C Wen, S J Johns, L Zhang, S-M Huang, K M Giacomini.   

Abstract

Drug transporters play a key role in the absorption, distribution, and elimination of many drugs, and they appear to be important determinants of therapeutic and adverse drug activities. Although a large body of data pertaining to drug transporters is available, there are few databases that inform drug developers, regulatory agencies, and academic scientists about transporters that are important in drug action and disposition. In this article, we inform the scientific community about the UCSF-FDA TransPortal, a new and valuable online resource for research and drug development.

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Year:  2012        PMID: 23085876      PMCID: PMC3974775          DOI: 10.1038/clpt.2012.44

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  1 in total

Review 1.  Membrane transporters in drug development.

Authors:  Kathleen M Giacomini; Shiew-Mei Huang; Donald J Tweedie; Leslie Z Benet; Kim L R Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M Hillgren; Keith A Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B Kim; Caroline A Lee; Mikko Niemi; Joseph W Polli; Yuichi Sugiyama; Peter W Swaan; Joseph A Ware; Stephen H Wright; Sook Wah Yee; Maciej J Zamek-Gliszczynski; Lei Zhang
Journal:  Nat Rev Drug Discov       Date:  2010-03       Impact factor: 84.694

  1 in total
  49 in total

Review 1.  The organic anion transporter (OAT) family: a systems biology perspective.

Authors:  Sanjay K Nigam; Kevin T Bush; Gleb Martovetsky; Sun-Young Ahn; Henry C Liu; Erin Richard; Vibha Bhatnagar; Wei Wu
Journal:  Physiol Rev       Date:  2015-01       Impact factor: 37.312

2.  Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation.

Authors:  Jeremiah D Momper; Jin Yang; Mary Gockenbach; Florin Vaida; Sanjay K Nigam
Journal:  Clin J Am Soc Nephrol       Date:  2019-03-18       Impact factor: 8.237

Review 3.  The Placental Barrier: the Gate and the Fate in Drug Distribution.

Authors:  Nino Tetro; Sonia Moushaev; Miriam Rubinchik-Stern; Sara Eyal
Journal:  Pharm Res       Date:  2018-02-23       Impact factor: 4.200

4.  Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors.

Authors:  Wei Wu; Kevin T Bush; Henry C Liu; Christopher Zhu; Ruben Abagyan; Sanjay K Nigam
Journal:  Drug Metab Dispos       Date:  2015-09-10       Impact factor: 3.922

5.  Physiology-based pharmacokinetics of caspofungin for adults and paediatrics.

Authors:  Felix Stader; Gudrun Wuerthwein; Andreas H Groll; Joerg-Janne Vehreschild; Oliver A Cornely; Georg Hempel
Journal:  Pharm Res       Date:  2014-12-19       Impact factor: 4.200

6.  Clinical Investigation of Coproporphyrins as Sensitive Biomarkers to Predict Mild to Strong OATP1B-Mediated Drug-Drug Interactions.

Authors:  Annett Kunze; Emmanuel Njumbe Ediage; Lieve Dillen; Mario Monshouwer; Jan Snoeys
Journal:  Clin Pharmacokinet       Date:  2018-12       Impact factor: 6.447

Review 7.  Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy.

Authors:  Hadas Han; Aniv Mann; Dana Ekstein; Sara Eyal
Journal:  AAPS J       Date:  2017-05-26       Impact factor: 4.009

8.  Quantitative structure-pharmacokinetic relationships for the prediction of renal clearance in humans.

Authors:  Rutwij A Dave; Marilyn E Morris
Journal:  Drug Metab Dispos       Date:  2014-10-28       Impact factor: 3.922

9.  Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.

Authors:  S W Yee; M M Giacomini; C-H Hsueh; D Weitz; X Liang; S Goswami; J M Kinchen; A Coelho; A A Zur; K Mertsch; W Brian; D L Kroetz; K M Giacomini
Journal:  Clin Pharmacol Ther       Date:  2016-09-20       Impact factor: 6.875

10.  Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters.

Authors:  Gleb Martovetsky; James B Tee; Sanjay K Nigam
Journal:  Mol Pharmacol       Date:  2013-09-13       Impact factor: 4.436

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