Literature DB >> 2308469

Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer.

S Ohta1, O Tachikawa, Y Makino, Y Tasaki, M Hirobe.   

Abstract

4-Hydroxytetrahydroisoquinoline (4OH-TIQ) was detected as a metabolite of a possible parkinsonism-inducing substance, tetrahydroisoquinoline (TIQ), in rat liver microsomes and rat urine. Urinary excretion of 4OH-TIQ was significantly reduced in female DA rat, an animal model of a poor debrisoquine metabolizer. The female DA rat also showed significantly higher brain accumulation of TIQ. These results suggest that the metabolic detoxication process is depressed and TIQ accumulation in the brain is enhanced in a poor debrisoquine metabolizer, which may be one possible explanation for poor debrisoquine metabolizers being susceptible to Parkinson's disease.

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Year:  1990        PMID： 2308469     DOI： 10.1016/0024-3205(90)90128-e

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  6 in total

Review 1.  Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.

Authors:  Sharawan Yadav; Anubhuti Dixit; Sonal Agrawal; Ashish Singh; Garima Srivastava; Anand Kumar Singh; Pramod Kumar Srivastava; Om Prakash; Mahendra Pratap Singh
Journal:  Mol Neurobiol       Date:  2012-06-27       Impact factor: 5.590

2.  A novel cytochrome P-450IID6 (CYPIID6) mutant gene associated with multiple system atrophy.

Authors:  K Iwahashi; R Miyatake; Y Tsuneoka; Y Matsuo; Y Ichikawa; K Hosokawa; K Sato; T Hayabara
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-02       Impact factor: 10.154

3.  Overexpression of CYP2D6 attenuates the toxicity of MPP+ in actively dividing and differentiated PC12 cells.

Authors:  Naomi Matoh; Seigo Tanaka; Masanori Takehashi; Marek Banasik; Todd Stedeford; Eliezer Masliah; Shigehiko Suzuki; Yoshihiko Nishimura; Kunihiro Ueda
Journal:  Gene Expr       Date:  2003

4.  Effects of salsolinol on cultivated endothelial cells.

Authors:  M F Melzig; J Zipper
Journal:  Neurochem Res       Date:  1993-06       Impact factor: 3.996

Review 5.  Biomarker research in neurotoxicology: the role of mechanistic studies to bridge the gap between the laboratory and epidemiological investigations.

Authors:  L G Costa
Journal:  Environ Health Perspect       Date:  1996-03       Impact factor: 9.031

Review 6.  Brain sites of movement disorder: genetic and environmental agents in neurodevelopmental perturbations.

Authors:  T Palomo; R J Beninger; R M Kostrzewa; T Archer
Journal:  Neurotox Res       Date:  2003       Impact factor: 3.978
  6 in total

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