Literature DB >> 23083755

Pathophysiology of new bone formation and ankylosis in spondyloarthritis.

Rik J U Lories1, Georg Schett.   

Abstract

The outcome of patients suffering from spondyloarthritis is determined by chronic inflammation and new bone formation leading to ankylosis. The latter process manifests by new cartilage and bone formation leading to joint or spine fusion. This article discusses the main mechanisms of new bone formation in spondyloarthritis. It reviews the key molecules and concepts of new bone formation and ankylosis in animal models of disease and translates these findings to human disease. In addition, proposed biomarkers of new bone formation are evaluated and the translational current and future challenges are discussed with regards to new bone formation in spondyloarthritis.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 23083755     DOI： 10.1016/j.rdc.2012.08.003

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  27 in total

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3.  Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis.

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Review 8.  Juvenile Spondyloarthritis: What More Do We Know About HLA-B27, Enthesitis, and New Bone Formation?

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Journal:  Front Med (Lausanne)       Date:  2021-05-20

9.  MR signal in the sacroiliac joint space in spondyloarthritis: a new sign.

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Review 10.  Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts.

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