PURPOSE: While the overall prognosis of non-molecularly selected advanced non-small cell lung cancer (NSCLC) patients is poor, a subset of these patients has durable survival. We examined which clinical factors might be predictive for this favourable outcome. PATIENTS AND METHODS: Long-term NSCLC survivors (LTS, i.e. >2 years) were retrieved from all our out- and in-patient contacts in a 6 month period (March-August 2009). LTS records were compared with a group of short-term survivors (STS). Both baseline clinical factors (sex, age, smoking status, weight loss, performance status, co-morbidity, histological subtype, place and number of metastasis) and treatment-related features (number and type of therapeutic lines, response, duration of treatment-free interval) were compared. RESULTS: 31 LTS were retrieved (stage IV patients with potentially radical treatment options, e.g. solitary brain or adrenal metastasis, were excluded), and compared with 34 STS. In the LTS group, median survival was 53 months, with 47% of patients alive at 5 years, in the STS patients this was 9.7 months, with 24% alive at 1-year. Baseline factors had little predictive value, but response to 1st line therapy (P = 0.0001), response duration (P = 0.009), and the number of systemic lines (P = 0.0023) were of importance. CONCLUSION: These data confirm the existence of LTS in patients with advanced NSCLC. There are very little clinical factors at the time of diagnosis that help to distinguish future LTS from STS patients. Factors related to the effect of 1st line treatment are important, and further prospects of patients achieving a 2-year survival are in general quite good.
PURPOSE: While the overall prognosis of non-molecularly selected advanced non-small cell lung cancer (NSCLC) patients is poor, a subset of these patients has durable survival. We examined which clinical factors might be predictive for this favourable outcome. PATIENTS AND METHODS: Long-term NSCLC survivors (LTS, i.e. >2 years) were retrieved from all our out- and in-patient contacts in a 6 month period (March-August 2009). LTS records were compared with a group of short-term survivors (STS). Both baseline clinical factors (sex, age, smoking status, weight loss, performance status, co-morbidity, histological subtype, place and number of metastasis) and treatment-related features (number and type of therapeutic lines, response, duration of treatment-free interval) were compared. RESULTS: 31 LTS were retrieved (stage IV patients with potentially radical treatment options, e.g. solitary brain or adrenal metastasis, were excluded), and compared with 34 STS. In the LTS group, median survival was 53 months, with 47% of patients alive at 5 years, in the STS patients this was 9.7 months, with 24% alive at 1-year. Baseline factors had little predictive value, but response to 1st line therapy (P = 0.0001), response duration (P = 0.009), and the number of systemic lines (P = 0.0023) were of importance. CONCLUSION: These data confirm the existence of LTS in patients with advanced NSCLC. There are very little clinical factors at the time of diagnosis that help to distinguish future LTS from STS patients. Factors related to the effect of 1st line treatment are important, and further prospects of patients achieving a 2-year survival are in general quite good.
Authors: Jessica J Lin; Stephanie Cardarella; Christine A Lydon; Suzanne E Dahlberg; David M Jackman; Pasi A Jänne; Bruce E Johnson Journal: J Thorac Oncol Date: 2015-12-25 Impact factor: 15.609
Authors: C S Higano; J Berlin; M Gordon; P LoRusso; S Tang; A Dontabhaktuni; J D Schwartz; J Cosaert; J M Mehnert Journal: Invest New Drugs Date: 2015-03-07 Impact factor: 3.651
Authors: Jennifer S Davis; Erin Prophet; Ho-Lan Peng; Hwa Young Lee; Rebecca S S Tidwell; J Jack Lee; Anish Thomas; Eva Szabo; Shine Chang Journal: JNCI Cancer Spectr Date: 2019-04-15
Authors: Rachel Evans; Kelvin Lee; Paul K Wallace; Mary Reid; Jason Muhitch; Askia Dozier; Circe Mesa; Patricia L Luaces; Orestes Santos-Morales; Adrienne Groman; Carlos Cedeno; Aileen Cinquino; Daniel T Fisher; Igor Puzanov; Mateusz Opyrchal; Christos Fountzilas; Tong Dai; Marc Ernstoff; Kristopher Attwood; Alan Hutson; Candace Johnson; Zaima Mazorra; Danay Saavedra; Kalet Leon; Agustin Lage; Tania Crombet; Grace K Dy Journal: Front Oncol Date: 2022-08-03 Impact factor: 5.738