Literature DB >> 2308237

Nitroarginine inhibits endothelium-derived relaxation.

Y Kobayashi1, K Hattori.   

Abstract

Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 10(2) microM NO2Arg was reduced to 10.1 +/- 4.3% (n = 5). L-arginine (10(2) microM) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO2Arg. These results indicate that NO2Arg is a novel inhibitor of endothelium-derived relaxation.

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Year:  1990        PMID： 2308237     DOI： 10.1254/jjp.52.167

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN： 0021-5198


  11 in total

1.  Involvement of nitric oxide pathway in the PAF-induced relaxation of rat thoracic aorta.

Authors:  H Moritoki; T Hisayama; S Takeuchi; H Miyano; W Kondoh
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739

2.  Involvement of accumulated endogenous NOS inhibitors and decreased NOS activity in the impaired neurogenic relaxation of the rabbit proximal urethra with ischaemia.

Authors:  H Masuda; T Tsujii; T Okuno; K Kihara; M Goto; H Azuma
Journal:  Br J Pharmacol       Date:  2001-05       Impact factor: 8.739

3.  Intimal hyperplasia in human uterine arteries accompanied by impaired synergism between prostaglandin I2 and nitric oxide.

Authors:  S Obayashi; T Aso; J Sato; H Hamasaki; H Azuma
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

4.  Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia.

Authors:  H Masuda; M Goto; S Tamaoki; H Azuma
Journal:  Br J Pharmacol       Date:  1999-01       Impact factor: 8.739

5.  Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

Authors:  D D Rees; R M Palmer; R Schulz; H F Hodson; S Moncada
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

6.  Possible dependence of pressor and heart rate effects of NG-nitro-L-arginine on autonomic nerve activity.

Authors:  Y X Wang; C C Pang
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739

7.  A comparison of the inhibitory effects of sodium nitroprusside, pinacidil and nifedipine on pressor response to NG-nitro-L-arginine.

Authors:  Y X Wang; T Zhou; C C Pang
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

8.  Prevention of intimal thickening after endothelial removal by a nonpeptide angiotensin II receptor antagonist, losartan.

Authors:  H Azuma; Y Niimi; H Hamasaki
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

9.  Endothelium-dependent relaxation of rabbit middle cerebral artery to a histamine H3-agonist is reduced by inhibitors of nitric oxide and prostacyclin synthesis.

Authors:  L Ea Kim; J Javellaud; N Oudart
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

10.  Role of endothelium in the human uterine arteries during normal menstrual cycle.

Authors:  H Azuma; S Obayashi; H Hamasaki; T Koyama; T Aso
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739
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