Literature DB >> 23081813

In vivo efficacy of a chimeric peptide derived from the conserved region of the M protein against group C and G streptococci.

Therese Nordström1, Jessica Malcolm, Graham Magor, Michael F Good, Michael R Batzloff.   

Abstract

The J8 peptide from the conserved region of the M protein protects against group A streptococcus infections. In this study, we demonstrate that vaccination with a J8-containing formulation induces IgG that recognizes and binds group C and G streptococci. Moreover, this formulation has the potential to provide protection against infections caused by these organisms.

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Year:  2012        PMID： 23081813      PMCID： PMC3535862          DOI： 10.1128/CVI.00140-12

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  31 in total

1.  Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci.

Authors:  Rebecca J Towers; Daniel Gal; David McMillan; Kadaba S Sriprakash; Bart J Currie; Mark J Walker; Gursharan S Chhatwal; Peter K Fagan
Journal:  J Clin Microbiol       Date:  2004-11       Impact factor: 5.948

2.  Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions.

Authors:  Mark R Davies; Thanh N Tran; David J McMillan; Donald L Gardiner; Bart J Currie; Kadaba S Sriprakash
Journal:  Microbes Infect       Date:  2005-04-19       Impact factor: 2.700

Review 3.  Pyogenic streptococci of Lancefield groups C and G as pathogens in man.

Authors:  A Efstratiou
Journal:  Soc Appl Bacteriol Symp Ser       Date:  1997

4.  Genetic mosaic upstream of scpG in human group G streptococci contains sequences from group A streptococcal virulence regulon.

Authors:  K S Sriprakash; J Hartas
Journal:  Adv Exp Med Biol       Date:  1997       Impact factor: 2.622

5.  Mapping the minimal murine T cell and B cell epitopes within a peptide vaccine candidate from the conserved region of the M protein of group A streptococcus.

Authors:  W A Hayman; E R Brandt; W A Relf; J Cooper; A Saul; M F Good
Journal:  Int Immunol       Date:  1997-11       Impact factor: 4.823

6.  Lateral genetic transfers between group A and G streptococci for M-like genes are ongoing.

Authors:  K S Sriprakash; J Hartas
Journal:  Microb Pathog       Date:  1996-05       Impact factor: 3.738

7.  M protein of a Streptococcus dysgalactiae human wound isolate shows multiple binding to different plasma proteins and shares epitopes with keratin and human cartilage.

Authors:  A Geyer; A Roth; S Vettermann; E Günther; A Groh; E Straube; K Schmidt
Journal:  FEMS Immunol Med Microbiol       Date:  1999-10

8.  Opsonic human antibodies from an endemic population specific for a conserved epitope on the M protein of group A streptococci.

Authors:  E R Brandt; W A Hayman; B Currie; J Carapetis; Y Wood; D C Jackson; J Cooper; W D Melrose; A J Saul; M F Good
Journal:  Immunology       Date:  1996-11       Impact factor: 7.397

9.  Rheumatic fever-associated Streptococcus pyogenes isolates aggregate collagen.

Authors:  Katrin Dinkla; Manfred Rohde; Wouter T M Jansen; Edward L Kaplan; Gursharan S Chhatwal; Susanne R Talay
Journal:  J Clin Invest       Date:  2003-06       Impact factor: 14.808

10.  Towards a vaccine for rheumatic fever: identification of a conserved target epitope on M protein of group A streptococci.

Authors:  S Pruksakorn; B Currie; E Brandt; D Martin; A Galbraith; C Phornphutkul; S Hunsakunachai; A Manmontri; M F Good
Journal:  Lancet       Date:  1994-09-03       Impact factor: 79.321
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