Yoshiro Toyama1, Kazuo Chin2, Yuichi Chihara1, Misa Takegami3, Ken-Ichi Takahashi4, Kensuke Sumi5, Takaya Nakamura6, Yukiyo Nakayama-Ashida7, Itsunari Minami7, Sachiko Horita8, Yasunori Oka9, Tomoko Wakamura10, Shun-Ichi Fukuhara11, Michiaki Mishima1, Hiroshi Kadotani12. 1. Department of Respiratory Medicine, Kyoto University, Kyoto. 2. Respiratory Care and Sleep Control Medicine, Kyoto University, Kyoto. Electronic address: chink@kuhp.kyoto-u.ac.jp. 3. Department of Epidemiology and Healthcare Research, Graduate School of Medicine and Public Health, Kyoto University, Kyoto; Department of Prevalence Medicine and Epidemiologic Informatics, Research and Development Initiative Center, National Cerebral and Cardiovascular Center, Osaka. 4. Department of Respiratory Medicine, Otsu Red Cross Hospital, Shiga. 5. Department of Respiratory Medicine, National Hospital Organization Minami Kyoto Hospital, Kyoto. 6. Department of Respiratory Medicine, Kyoto City Hospital, Kyoto. 7. Horizontal Medical Research Organization, Kyoto University, Kyoto. 8. Department of Human Nursing, Faculty of Human Health, Sonoda Women's University, Hyogo. 9. Department of Sleep Control Medicine (Dr Oka), Graduate School of Medicine, Ehime University, Ehime, Japan. 10. Environmental Health Nursing, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto. 11. Department of Epidemiology and Healthcare Research, Graduate School of Medicine and Public Health, Kyoto University, Kyoto. 12. Center for Genomic Medicine, Kyoto University, Kyoto.
Abstract
BACKGROUND: Dyslipidemia is often comorbid with obstructive sleep apnea (OSA), but few population-based studies have investigated their relationship. Short sleep duration is associated with hypertension and diabetes; however, its association with dyslipidemia is not well known. We investigated relationships among OSA, sleep duration, and the lipid profile in a community-based study. METHODS: We measured the respiratory disturbance index (RDI) and sleep duration by a type 3 portable device and actigraph in 275 men in a Japanese company. Fasting blood parameters were obtained from periodic inspection data. RESULTS: According to Japanese criteria, 143 subjects had dyslipidemia. Percent sleep time of oxygen saturation as measured by pulse oximetry (SpO2) < 90% and prevalence of severe OSA were greater and sleep duration and mean SpO2 during sleep were lower in subjects with dyslipidemia than in those without. Univariate analysis showed that the RDI was positively correlated with serum triglyceride (TG) levels (ρ = 0.20, P < .01), and sleep duration was negatively correlated with serum total cholesterol (TC) levels (γ = -0.13, P = .03) and serum low-density lipoprotein cholesterol levels (γ = -0.12, P = .04). Stepwise multiple regression analysis revealed that TG was correlated with RDI (β = 0.14, P = .02), BMI (β = 0.20, P < .01), and alcohol intake (β = 0.20, P < .01), and that TC was correlated with sleep duration (β = -0.13, P = .03), age (β = 0.15, P = .02), and waist/hip ratio (β = 0.15, P = .02). CONCLUSIONS: Short sleep duration was associated with TC levels and RDI was positively associated with TG levels among working-aged men in an urban Japanese company. Correcting the status of OSA and/or short sleep duration might improve the lipid profile and cardiovascular consequences.
BACKGROUND:Dyslipidemia is often comorbid with obstructive sleep apnea (OSA), but few population-based studies have investigated their relationship. Short sleep duration is associated with hypertension and diabetes; however, its association with dyslipidemia is not well known. We investigated relationships among OSA, sleep duration, and the lipid profile in a community-based study. METHODS: We measured the respiratory disturbance index (RDI) and sleep duration by a type 3 portable device and actigraph in 275 men in a Japanese company. Fasting blood parameters were obtained from periodic inspection data. RESULTS: According to Japanese criteria, 143 subjects had dyslipidemia. Percent sleep time of oxygen saturation as measured by pulse oximetry (SpO2) &lt; 90% and prevalence of severe OSA were greater and sleep duration and mean SpO2 during sleep were lower in subjects with dyslipidemia than in those without. Univariate analysis showed that the RDI was positively correlated with serum triglyceride (TG) levels (ρ = 0.20, P &lt; .01), and sleep duration was negatively correlated with serum total cholesterol (TC) levels (γ = -0.13, P = .03) and serum low-density lipoprotein cholesterol levels (γ = -0.12, P = .04). Stepwise multiple regression analysis revealed that TG was correlated with RDI (β = 0.14, P = .02), BMI (β = 0.20, P &lt; .01), and alcohol intake (β = 0.20, P &lt; .01), and that TC was correlated with sleep duration (β = -0.13, P = .03), age (β = 0.15, P = .02), and waist/hip ratio (β = 0.15, P = .02). CONCLUSIONS: Short sleep duration was associated with TC levels and RDI was positively associated with TG levels among working-aged men in an urban Japanese company. Correcting the status of OSA and/or short sleep duration might improve the lipid profile and cardiovascular consequences.
Authors: Wagner A Silva; Bianca Almeida-Pititto; Ronaldo B Santos; Aline N Aielo; Soraya Giatti; Barbara K Parise; Silvana P Souza; Sandra F Vivolo; Paulo A Lotufo; Isabela M Bensenor; Luciano F Drager Journal: Sleep Breath Date: 2021-02-15 Impact factor: 2.816