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Literature DB >> 23080193

Therapeutic potential of targeting IL-17.

Sarah A Jones¹, Caroline E Sutton, Daniel Cua, Kingston H G Mills.

Abstract

A June 2012 meeting in Dublin, Ireland, showcased advances in the understanding of the role of IL-17 and related cytokines in host immunity and how these cytokines have been successfully targeted for the treatment of autoimmunity.

Entities: Disease Gene

Mesh：

Substances：

Year: 2012 PMID： 23080193 DOI： 10.1038/ni.2450

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

24 in total

1. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial.

Authors: Wolfgang Hueber; Bruce E Sands; Steve Lewitzky; Marc Vandemeulebroecke; Walter Reinisch; Peter D R Higgins; Jan Wehkamp; Brian G Feagan; Michael D Yao; Marek Karczewski; Jacek Karczewski; Nicole Pezous; Stephan Bek; Gerard Bruin; Bjoern Mellgard; Claudia Berger; Marco Londei; Arthur P Bertolino; Gervais Tougas; Simon P L Travis
Journal: Gut Date: 2012-05-17 Impact factor: 23.059

2. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.

Authors: Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo
Journal: Nature Date: 2006-04-30 Impact factor: 49.962

Review 3. Th17 cells in immunity to Candida albicans.

Authors: Nydiaris Hernández-Santos; Sarah L Gaffen
Journal: Cell Host Microbe Date: 2012-05-17 Impact factor: 21.023

4. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

Authors: Ivaylo I Ivanov; Brent S McKenzie; Liang Zhou; Carlos E Tadokoro; Alice Lepelley; Juan J Lafaille; Daniel J Cua; Dan R Littman
Journal: Cell Date: 2006-09-22 Impact factor: 41.582

5. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation.

Authors: Ying Li; Silvia Innocentin; David R Withers; Natalie A Roberts; Alec R Gallagher; Elena F Grigorieva; Christoph Wilhelm; Marc Veldhoen
Journal: Cell Date: 2011-10-13 Impact factor: 41.582

6. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2).

Authors: Kim A Papp; Richard G Langley; Mark Lebwohl; Gerald G Krueger; Philippe Szapary; Newman Yeilding; Cynthia Guzzo; Ming-Chun Hsu; Yuhua Wang; Shu Li; Lisa T Dooley; Kristian Reich
Journal: Lancet Date: 2008-05-17 Impact factor: 79.321

7. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

Authors: Caroline E Sutton; Stephen J Lalor; Cheryl M Sweeney; Corinna F Brereton; Ed C Lavelle; Kingston H G Mills
Journal: Immunity Date: 2009-08-13 Impact factor: 31.745

8. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

Authors: Marc Veldhoen; Richard J Hocking; Christopher J Atkins; Richard M Locksley; Brigitta Stockinger
Journal: Immunity Date: 2006-02 Impact factor: 31.745

9. Interleukin-17 is a negative regulator of established allergic asthma.

Authors: Silvia Schnyder-Candrian; Dieudonnée Togbe; Isabelle Couillin; Isabelle Mercier; Frank Brombacher; Valérie Quesniaux; Francois Fossiez; Bernhard Ryffel; Bruno Schnyder
Journal: J Exp Med Date: 2006-11-13 Impact factor: 14.307

10. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

Authors: Caroline Sutton; Corinna Brereton; Brian Keogh; Kingston H G Mills; Ed C Lavelle
Journal: J Exp Med Date: 2006-07-03 Impact factor: 14.307

26 in total

Review 1. Glucocorticoids in 2015: New answers to old problems.

Authors: Sarah A Jones; Eric F Morand
Journal: Nat Rev Rheumatol Date: 2015-12-24 Impact factor: 20.543

2. Identification of the salmonid IL-17A/F1a/b, IL-17A/F2b, IL-17A/F3 and IL-17N genes and analysis of their expression following in vitro stimulation and infection.

Authors: Tiehui Wang; Yousheng Jiang; Alex Wang; Mansourah Husain; Qiaoqing Xu; Christopher J Secombes
Journal: Immunogenetics Date: 2015-05-06 Impact factor: 2.846

3. CXCL5 drives neutrophil recruitment in TH17-mediated GN.

Authors: Erik M Disteldorf; Christian F Krebs; Hans-Joachim Paust; Jan-Eric Turner; Geraldine Nouailles; André Tittel; Catherine Meyer-Schwesinger; Gesa Stege; Silke Brix; Joachim Velden; Thorsten Wiech; Udo Helmchen; Oliver M Steinmetz; Anett Peters; Sabrina B Bennstein; Anna Kaffke; Chrystel Llanto; Sergio A Lira; Hans-Willi Mittrücker; Rolf A K Stahl; Christian Kurts; Stefan H E Kaufmann; Ulf Panzer
Journal: J Am Soc Nephrol Date: 2014-06-05 Impact factor: 10.121

Review 4. The paradoxical role of tumor-infiltrating immune cells in lung cancer.

Authors: Xiaodan Zheng; Yuhai Hu; Chengfang Yao
Journal: Intractable Rare Dis Res Date: 2017-11

5. Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model.

Authors: Qiuyang Zhang; Sen Liu; Dongxia Ge; David M Cunningham; Feng Huang; Lin Ma; Thomas P Burris; Zongbing You
Journal: Prostate Date: 2017-02-27 Impact factor: 4.104

6. Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists.

Authors: Xiao Hu; Yahong Wang; Ling-Yang Hao; Xikui Liu; Chuck A Lesch; Brian M Sanchez; Jay M Wendling; Rodney W Morgan; Tom D Aicher; Laura L Carter; Peter L Toogood; Gary D Glick
Journal: Nat Chem Biol Date: 2015-01-05 Impact factor: 15.040

Review 7. Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases.

Authors: Pradeep K Dagur; J Philip McCoy
Journal: Autoimmun Rev Date: 2015-01-13 Impact factor: 9.754