David Dubayle1, Anne Héron. 1. Laboratory of Neurophysics and Physiology, CNRS UMR 8119, Paris Descartes University, 45 Rue Des Saints Pères, 75270 Paris, France.
Abstract
INTRODUCTION: The mast cell is an immunocyte, but its functions in the brain remain unclear. MATERIALS AND METHODS: In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population. CONCLUSION: We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.
INTRODUCTION: The mast cell is an immunocyte, but its functions in the brain remain unclear. MATERIALS AND METHODS: In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population. CONCLUSION: We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.
Authors: N P Turrin; D Gayle; S E Ilyin; M C Flynn; W Langhans; G J Schwartz; C R Plata-Salamán Journal: Brain Res Bull Date: 2001-03-01 Impact factor: 4.077