Literature DB >> 23079527

Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans.

Narender Reddy Emmadi1, Krishnaiah Atmakur, Ganesh Kumar Chityal, Sujitha Pombala, Jagadeesh Babu Nanubolu.   

Abstract

A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23079527     DOI： 10.1016/j.bmcl.2012.09.018

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Crystal structures of two 4H-chromene derivatives: 2-amino-3-cyano-4-(3,4-di-chloro-phen-yl)-7-hy-droxy-4H-benzo[1,2-b]pyran 1,4-dioxane monosolvate and 2-amino-3-cyano-4-(2,6-di-chloro-phen-yl)-7-hy-droxy-4H-benzo[1,2-b]pyran.

Authors:  S Silambarasan; A Jamal Abdul Nasser; T Mohandas
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-09-27

2.  Synthesis and characterization of amino glucose-functionalized silica-coated NiFe2O4 nanoparticles: a heterogeneous, new and magnetically separable catalyst for the solvent-free synthesis of pyrano[3,2-c]chromen-5(4H)-ones.

Authors:  Leila Zare Fekri; Mohammad Nikpassand; Sakineh Pourmirzajani; Behnaz Aghazadeh
Journal:  RSC Adv       Date:  2018-06-19       Impact factor: 4.036

3.  Investigation on the Binding Mode of 3, 4-Dihydropyrano[c]Chromene Derivative with Double Strand DNA.

Authors:  Mahvash Farajzadeh Dehkordi; Gholamreza Dehghan; Majid Mahdavi; Mohammad Ali Hosseinpour Feizi
Journal:  Adv Pharm Bull       Date:  2015-11-30

4.  Crystal structure of ethyl (4R)-2-amino-7-hy-droxy-4-phenyl-4H-chromene-3-carboxyl-ate.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Sabry H H Younes; Mustafa R Albayati
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-06-27
  4 in total

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