Literature DB >> 23076133

VEGF-initiated angiogenesis and the uPA/uPAR system.

Johannes M Breuss1, Pavel Uhrin.   

Abstract

Angiogenesis involves a series of tightly regulated cellular processes initiated primarily by the vascular endothelial growth factor (VEGF). The urokinase-type plasminogen activator system, consisting of the urokinase-type plasminogen activator (uPA), its cellular receptor uPAR and its inhibitor PAI-1, participates in the realization of these VEGF-induced processes by activating pericellular proteolysis, increasing vascular permeability and by supporting endothelial cell proliferation and migration.

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Year:  2012        PMID： 23076133      PMCID： PMC3547900          DOI： 10.4161/cam.22243

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  80 in total

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