Literature DB >> 23075170

Acid-labile Cys-protecting groups for the Fmoc/tBu strategy: filling the gap.

Miriam Góngora-Benítez1, Lorena Mendive-Tapia, Iván Ramos-Tomillero, Arjen C Breman, Judit Tulla-Puche, Fernando Albericio.   

Abstract

To address the existing gap in the current set of acid-labile Cys-protecting groups for the Fmoc/tBu strategy, diverse Fmoc-Cys(PG)-OH derivatives were prepared and incorporated into a model tripeptide to study their stability against TFA. S-Dpm proved to be compatible with the commonly used S-Trt group and was applied for the regioselecive construction of disulfide bonds.

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Year:  2012        PMID： 23075170     DOI： 10.1021/ol302550p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

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2.  Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis.

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Journal:  J Pept Sci       Date:  2013-11-28       Impact factor: 1.905

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Journal:  Int J Mol Sci       Date:  2020-02-17       Impact factor: 5.923

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Authors:  Jeremiah D Osteen; Volker Herzig; John Gilchrist; Joshua J Emrick; Chuchu Zhang; Xidao Wang; Joel Castro; Sonia Garcia-Caraballo; Luke Grundy; Grigori Y Rychkov; Andy D Weyer; Zoltan Dekan; Eivind A B Undheim; Paul Alewood; Cheryl L Stucky; Stuart M Brierley; Allan I Basbaum; Frank Bosmans; Glenn F King; David Julius
Journal:  Nature       Date:  2016-06-06       Impact factor: 49.962

6.  Understanding acid lability of cysteine protecting groups.

Authors:  Iván Ramos-Tomillero; Lorena Mendive-Tapia; Miriam Góngora-Benítez; Ernesto Nicolás; Judit Tulla-Puche; Fernando Albericio
Journal:  Molecules       Date:  2013-05-06       Impact factor: 4.411
  6 in total

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