Zahra Razavi1, Alireza Yavarikia, Saadat Torabian. 1. Associate Professor, Pediatric Endocrinologist, Pediatrics Department, Faculty of Medicine, Hamedan University of Medical Sciences.
Abstract
OBJECTIVE: Congenital hypothyroidism is characterized by inadequate thyroid hormone production in newborn infants. Many infants with CH have co-occurring congenital malformations. This is an investigation on the frequency and types of congenital anomalies in infants with congenital hypothyroidism born from May 2006-2010 in Hamadan, west province of Iran. METHODS: The Iranian neonatal screening program for congenital hypothyroidism was initiated in May 2005. This prospective descriptive study was conducted in infants diagnosed with congenital hypothyroidism being followed up in Pediatric Endocrinology Clinic of Besat Hospital, a tertiary care centre in Hamadan. Cases included all infants with congenital hypothyroidism diagnosed through newborn screening program or detected clinically. Anomalies were identified by clinical examination, echocardiography, and X-ray of the hip during the infant's first year of life. RESULTS: A total of 150 infants with biochemically confirmed primary congenital hypothyroidism (72 females and 78 males) were recruited during the period between May 2006-2010. Overall, 30 (20%) infants had associated congenital anomalies. The most common type of anomaly was Down syndrome. Seven infants (3.1%) had congenital cardiac anomalies such as: ASD (n=3), VSD (n=2), PS (n =1), PDA (n=1). Three children (2.6%) had developmental dysplasia of the hip (n=3). CONCLUSION: The overall frequency of Down syndrome, cardiac malformation and other birth defect was high in infants with CH. This reinforces the need to examine all infants with congenital hypothyroidism for the presence of associated congenital anomalies.
OBJECTIVE:Congenital hypothyroidism is characterized by inadequate thyroid hormone production in newborn infants. Many infants with CH have co-occurring congenital malformations. This is an investigation on the frequency and types of congenital anomalies in infants with congenital hypothyroidism born from May 2006-2010 in Hamadan, west province of Iran. METHODS: The Iranian neonatal screening program for congenital hypothyroidism was initiated in May 2005. This prospective descriptive study was conducted in infants diagnosed with congenital hypothyroidism being followed up in Pediatric Endocrinology Clinic of Besat Hospital, a tertiary care centre in Hamadan. Cases included all infants with congenital hypothyroidism diagnosed through newborn screening program or detected clinically. Anomalies were identified by clinical examination, echocardiography, and X-ray of the hip during the infant's first year of life. RESULTS: A total of 150 infants with biochemically confirmed primary congenital hypothyroidism (72 females and 78 males) were recruited during the period between May 2006-2010. Overall, 30 (20%) infants had associated congenital anomalies. The most common type of anomaly was Down syndrome. Seven infants (3.1%) had congenital cardiac anomalies such as: ASD (n=3), VSD (n=2), PS (n =1), PDA (n=1). Three children (2.6%) had developmental dysplasia of the hip (n=3). CONCLUSION: The overall frequency of Down syndrome, cardiac malformation and other birth defect was high in infants with CH. This reinforces the need to examine all infants with congenital hypothyroidism for the presence of associated congenital anomalies.
Authors: A S P van Trotsenburg; T Vulsma; H M van Santen; W Cheung; J J M de Vijlder Journal: J Clin Endocrinol Metab Date: 2003-04 Impact factor: 5.958
Authors: Cynthia F Hinton; Katharine B Harris; Lynette Borgfeld; Margaret Drummond-Borg; Roger Eaton; Fred Lorey; Bradford L Therrell; Jill Wallace; Kenneth A Pass Journal: Pediatrics Date: 2010-05 Impact factor: 7.124
Authors: M J E Kempers; C I Lanting; A F J van Heijst; A S P van Trotsenburg; B M Wiedijk; J J M de Vijlder; T Vulsma Journal: J Clin Endocrinol Metab Date: 2006-06-20 Impact factor: 5.958
Authors: Susan R Rose; Rosalind S Brown; Thomas Foley; Paul B Kaplowitz; Celia I Kaye; Sumana Sundararajan; Surendra K Varma Journal: Pediatrics Date: 2006-06 Impact factor: 7.124
Authors: A Olivieri; M A Stazi; P Mastroiacovo; C Fazzini; E Medda; A Spagnolo; S De Angelis; M E Grandolfo; D Taruscio; V Cordeddu; M Sorcini Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958