AIMS: Primary peritoneal serous carcinoma (PPSC) is an unusual neoplasm that has not been properly characterized. To better define the clinicopathological and immunohistochemical features of PPSC, we present 6 such cases. METHODS: The 6 patients consisted of one man and 5 women, ranging in age from 45 and 75 years. None of the patients had any history or clinical evidence of tumor elsewhere. The immunohistochemical profile was examined using antibodies against β-catenin, E-cadherin, wnt5a, EGFR, VEGF, vimentin, Ki67, and P53. RESULTS: Of all the 6 PPSC cases, 5 cases presented stage IIIC and 1 case presented stage IV. Microscopically, 5 cases were poorly differentiated and 1 was moderately differentiated. All cases showed positive staining for β-catenin, E-cadherin, vimentin, VEGF, P53, and Ki67, 4 cases expressed EGFR, and all cases were consistently negative for wnt5a. CONCLUSIONS: We described 6 cases of PPSC with clinicopathological and immunohistochemical features. The findings provide basic knowledge of PPSC.
AIMS: Primary peritoneal serous carcinoma (PPSC) is an unusual neoplasm that has not been properly characterized. To better define the clinicopathological and immunohistochemical features of PPSC, we present 6 such cases. METHODS: The 6 patients consisted of one man and 5 women, ranging in age from 45 and 75 years. None of the patients had any history or clinical evidence of tumor elsewhere. The immunohistochemical profile was examined using antibodies against β-catenin, E-cadherin, wnt5a, EGFR, VEGF, vimentin, Ki67, and P53. RESULTS: Of all the 6 PPSC cases, 5 cases presented stage IIIC and 1 case presented stage IV. Microscopically, 5 cases were poorly differentiated and 1 was moderately differentiated. All cases showed positive staining for β-catenin, E-cadherin, vimentin, VEGF, P53, and Ki67, 4 cases expressed EGFR, and all cases were consistently negative for wnt5a. CONCLUSIONS: We described 6 cases of PPSC with clinicopathological and immunohistochemical features. The findings provide basic knowledge of PPSC.
Authors: Eldo T Verghese; Hrishikesh Shenoy; Victoria J Cookson; Caroline A Green; Jo Howarth; R H Partanen; Steven Pollock; Alison Waterworth; Valerie Speirs; Thomas A Hughes; Andrew M Hanby Journal: Histopathology Date: 2011-10 Impact factor: 5.087
Authors: J O Schorge; M G Muto; S J Lee; L W Huang; W R Welch; D A Bell; E Z Keung; R S Berkowitz; S C Mok Journal: Cancer Res Date: 2000-03-01 Impact factor: 12.701
Authors: Xiaoyun Liao; Michelle K Y Siu; Christy W H Au; Esther S Y Wong; Hoi Yan Chan; Philip P C Ip; Hextan Y S Ngan; Annie N Y Cheung Journal: Carcinogenesis Date: 2008-11-20 Impact factor: 4.944
Authors: Paolo Lido; Giovanni Paolino; Andrea Feliziani; Letizia Santurro; Mauro Montuori; Flavio de Sanctis; Piero Rossi; Giuseppe Petrella; Edoardo Ricciardi; Giuseppe Fusano; Orlandi Augusto; Patrizio Polisca Journal: An Bras Dermatol Date: 2015 Nov-Dec Impact factor: 1.896