Literature DB >> 23071300

Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.

Philip J J Robinson1, David A Bushnell, Michael J Trnka, Alma L Burlingame, Roger D Kornberg.   

Abstract

The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.

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Year:  2012        PMID： 23071300      PMCID： PMC3497735          DOI： 10.1073/pnas.1215241109

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

1.  Topographic studies of the GroEL-GroES chaperonin complex by chemical cross-linking using diformyl ethynylbenzene: the power of high resolution electron transfer dissociation for determination of both peptide sequences and their attachment sites.

Authors:  Michael J Trnka; A L Burlingame
Journal:  Mol Cell Proteomics       Date:  2010-09-02       Impact factor: 5.911

Review 2.  Mediator and the mechanism of transcriptional activation.

Authors:  Roger D Kornberg
Journal:  Trends Biochem Sci       Date:  2005-05       Impact factor: 13.807

3.  Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator.

Authors:  T Max M Søgaard; Jesper Q Svejstrup
Journal:  J Biol Chem       Date:  2007-03-21       Impact factor: 5.157

4.  RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.

Authors:  S M Liao; I C Taylor; R E Kingston; R A Young
Journal:  Genes Dev       Date:  1991-12       Impact factor: 11.361

5.  Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II.

Authors:  Roland Becker; Bernhard Loll; Anton Meinhart
Journal:  J Biol Chem       Date:  2008-06-11       Impact factor: 5.157

6.  Finding chimeras: a bioinformatics strategy for identification of cross-linked peptides.

Authors:  Feixia Chu; Peter R Baker; Alma L Burlingame; Robert J Chalkley
Journal:  Mol Cell Proteomics       Date:  2009-10-06       Impact factor: 5.911

7.  Conserved structures of mediator and RNA polymerase II holoenzyme.

Authors:  F J Asturias; Y W Jiang; L C Myers; C M Gustafsson; R D Kornberg
Journal:  Science       Date:  1999-02-12       Impact factor: 47.728

8.  Direct interaction of RNA polymerase II and mediator required for transcription in vivo.

Authors:  Julie Soutourina; Sandra Wydau; Yves Ambroise; Claire Boschiero; Michel Werner
Journal:  Science       Date:  2011-03-18       Impact factor: 47.728

9.  Mediator as a general transcription factor.

Authors:  Yuichiro Takagi; Roger D Kornberg
Journal:  J Biol Chem       Date:  2005-11-01       Impact factor: 5.157

10.  Structure of an RNA polymerase II-TFIIB complex and the transcription initiation mechanism.

Authors:  Xin Liu; David A Bushnell; Dong Wang; Guillermo Calero; Roger D Kornberg
Journal:  Science       Date:  2009-11-12       Impact factor: 47.728
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  61 in total

1.  Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition.

Authors:  Yanli Qi; Hui Liu; Jiayin Yu; Xiulai Chen; Liming Liu
Journal:  Appl Environ Microbiol       Date:  2017-08-31       Impact factor: 4.792

2.  Matching cross-linked peptide spectra: only as good as the worse identification.

Authors:  Michael J Trnka; Peter R Baker; Philip J J Robinson; A L Burlingame; Robert J Chalkley
Journal:  Mol Cell Proteomics       Date:  2013-12-12       Impact factor: 5.911

3.  Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α.

Authors:  Dotan Sela; Juliana J Conkright; Lu Chen; Joshua Gilmore; Michael P Washburn; Laurence Florens; Ronald C Conaway; Joan Weliky Conaway
Journal:  J Biol Chem       Date:  2013-07-17       Impact factor: 5.157

Review 4.  RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.

Authors:  Jeffry L Corden
Journal:  Chem Rev       Date:  2013-09-16       Impact factor: 60.622

Review 5.  Structural insights into transcription initiation by RNA polymerase II.

Authors:  Sebastian Grünberg; Steven Hahn
Journal:  Trends Biochem Sci       Date:  2013-10-11       Impact factor: 13.807

6.  Architecture of the RNA polymerase II-Mediator core initiation complex.

Authors:  C Plaschka; L Larivière; L Wenzeck; M Seizl; M Hemann; D Tegunov; E V Petrotchenko; C H Borchers; W Baumeister; F Herzog; E Villa; P Cramer
Journal:  Nature       Date:  2015-02-04       Impact factor: 49.962

7.  Core Mediator structure at 3.4 Å extends model of transcription initiation complex.

Authors:  Kayo Nozawa; Thomas R Schneider; Patrick Cramer
Journal:  Nature       Date:  2017-05-03       Impact factor: 49.962

8.  Chromatin potentiates transcription.

Authors:  Shigeki Nagai; Ralph E Davis; Pierre Jean Mattei; Kyle Patrick Eagen; Roger D Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-30       Impact factor: 11.205

9.  Genetic interaction analysis of point mutations enables interrogation of gene function at a residue-level resolution: exploring the applications of high-resolution genetic interaction mapping of point mutations.

Authors:  Hannes Braberg; Erica A Moehle; Michael Shales; Christine Guthrie; Nevan J Krogan
Journal:  Bioessays       Date:  2014-05-20       Impact factor: 4.345

Review 10.  Disordered proteinaceous machines.

Authors:  Monika Fuxreiter; Ágnes Tóth-Petróczy; Daniel A Kraut; Andreas Matouschek; Andreas T Matouschek; Roderick Y H Lim; Bin Xue; Lukasz Kurgan; Vladimir N Uversky
Journal:  Chem Rev       Date:  2014-04-04       Impact factor: 60.622
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