Narcolepsy-cataplexy (N-C) is a focal neurodegenerative disease with a genetic predisposition and autoimmune etiology; the pathogenesis of narcolepsy without cataplexy (Nw/oC) is less clear. One hundred and forty eight patients underwent clinical face-to face interviews, polysomnography, multiple sleep latency testing and HLA-DQB1*0602 typing. The cohort was divided into four age groups: children and adolescents under 19 years (N = 31), adults aged 20-39 years (N = 51), 40-59 years (N = 28) and over 60 years (N = 38). N-C was found in 93 adults (79.5 %) compared with 16 pediatric patients (51.6 %) (p < 0.01), suggesting that at least some of the children were candidates for developing cataplexy in the future. Statistical evaluation showed an increasing age-related proportion of associated sleep disorders-obstructive sleep apnea, periodic leg movements and restless leg syndrome (p < 0.001). Nw/oC patients showed sleep comorbidities less frequently than N-C group. A close connection with N-C was found particularly in REM behavior disorder (RBD) (p < 0.05). RBD affected a third of the patients in the youngest as well as in the oldest groups. However, association with other sleep disorders had no significant effect on nocturnal sleep (with the exception of obstructive sleep apnea), and the sleep comorbidities under study had no noticeable effect on daytime sleepiness.
Narcolepsy-cataplexy (N-C) is a focal n class="Disease">neurodegenerative disease with a genetic predisposition and autoimmune etiology; the pathogenesis of narcolepsy without cataplexy (Nw/oC) is less clear. One hundred and forty eight patients underwent clinical face-to face interviews, polysomnography, multiple sleep latency testing and HLA-DQB1*0602 typing. The cohort was divided into four age groups: children and adolescents under 19 years (N = 31), adults aged 20-39 years (N = 51), 40-59 years (N = 28) and over 60 years (N = 38). N-C was found in 93 adults (79.5 %) compared with 16 pediatric patients (51.6 %) (p < 0.01), suggesting that at least some of the children were candidates for developing cataplexy in the future. Statistical evaluation showed an increasing age-related proportion of associated sleep disorders-obstructive sleep apnea, periodic leg movements and restless leg syndrome (p < 0.001). Nw/oC patients showed sleep comorbidities less frequently than N-C group. A close connection with N-C was found particularly in REM behavior disorder (RBD) (p < 0.05). RBD affected a third of the patients in the youngest as well as in the oldest groups. However, association with other sleep disorders had no significant effect on nocturnal sleep (with the exception of obstructive sleep apnea), and the sleep comorbidities under study had no noticeable effect on daytime sleepiness.
Authors: Birgit Frauscher; Viola Gschliesser; Elisabeth Brandauer; Suzana V Schönwald; Tina Falkenstetter; Laura Ehrmann; Ismail Tokmak; Werner Poewe; Birgit Högl Journal: J Sleep Res Date: 2011-01-25 Impact factor: 3.981
Authors: Birgitte R Kornum; Minae Kawashima; Juliette Faraco; Ling Lin; Thomas J Rico; Stephanie Hesselson; Robert C Axtell; Hedwich Kuipers; Karin Weiner; Alexandra Hamacher; Matthias U Kassack; Fang Han; Stine Knudsen; Jing Li; Xiaosong Dong; Juliane Winkelmann; Giuseppe Plazzi; Sona Nevsimalova; Seung-Chul Hong; Yutaka Honda; Makoto Honda; Birgit Högl; Thanh G N Ton; Jacques Montplaisir; Patrice Bourgin; David Kemlink; Yu-Shu Huang; Simon Warby; Mali Einen; Jasmin L Eshragh; Taku Miyagawa; Alex Desautels; Elisabeth Ruppert; Per Egil Hesla; Francesca Poli; Fabio Pizza; Birgit Frauscher; Jong-Hyun Jeong; Sung-Pil Lee; Kingman P Strohl; William T Longstreth; Mark Kvale; Marie Dobrovolna; Maurice M Ohayon; Gerald T Nepom; H-Erich Wichmann; Guy A Rouleau; Christian Gieger; Douglas F Levinson; Pablo V Gejman; Thomas Meitinger; Paul Peppard; Terry Young; Poul Jennum; Lawrence Steinman; Katsushi Tokunaga; Pui-Yan Kwok; Neil Risch; Joachim Hallmayer; Emmanuel Mignot Journal: Nat Genet Date: 2010-12-19 Impact factor: 38.330
Authors: Birgit Frauscher; Laura Ehrmann; Thomas Mitterling; David Gabelia; Viola Gschliesser; Elisabeth Brandauer; Werner Poewe; Birgit Högl Journal: J Clin Sleep Med Date: 2013-08-15 Impact factor: 4.062