Literature DB >> 23070266

Investigations regarding the utility of prodigiosenes to treat leukemia.

Deborah A Smithen1, A Michael Forrester, Dale P Corkery, Graham Dellaire, Julie Colpitts, Sherri A McFarland, Jason N Berman, Alison Thompson.   

Abstract

Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

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Year:  2013        PMID： 23070266     DOI： 10.1039/c2ob26535d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

1.  Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117.

Authors:  Jelena Lazic; Sanja Skaro Bogojevic; Sandra Vojnovic; Ivana Aleksic; Dusan Milivojevic; Martin Kretzschmar; Tanja Gulder; Milos Petkovic; Jasmina Nikodinovic-Runic
Journal:  Molecules       Date:  2022-06-09       Impact factor: 4.927

2.  Danio rerio: Small Fish Making a Big Splash in Leukemia.

Authors:  Barbara Squiban; J Kimble Frazer
Journal:  Curr Pathobiol Rep       Date:  2014-06

3.  Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation.

Authors:  Beibei Zhang; Yasuhito Shimada; Junya Kuroyanagi; Noriko Umemoto; Yuhei Nishimura; Toshio Tanaka
Journal:  PLoS One       Date:  2014-01-15       Impact factor: 3.240

4.  Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization.

Authors:  Papireddy Kancharla; Wanli Lu; Shaimaa M Salem; Jane Xu Kelly; Kevin A Reynolds
Journal:  J Org Chem       Date:  2014-11-18       Impact factor: 4.354

5.  Inhibitory Growth of Oral Squamous Cell Carcinoma Cancer via Bacterial Prodigiosin.

Authors:  Ming-Fang Cheng; Chun-Shu Lin; Yu-Hsin Chen; Ping-Jyun Sung; Shian-Ren Lin; Yi-Wen Tong; Ching-Feng Weng
Journal:  Mar Drugs       Date:  2017-07-15       Impact factor: 5.118

6.  Study on the Anticancer Activity of Prodigiosin from Variants of Serratia Marcescens QBN VTCC 910026.

Authors:  Sy Le Thanh Nguyen; Tien Cuong Nguyen; Thi Tuyen Do; Trong Luong Vu; Thi Thao Nguyen; Thi Thao Do; Thi Hien Trang Nguyen; Thanh Hoang Le; Dinh Kha Trinh; Thi Anh Tuyet Nguyen
Journal:  Biomed Res Int       Date:  2022-04-25       Impact factor: 3.246

7.  A step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes.

Authors:  Carlotta Figliola; Estelle Marchal; Brandon R Groves; Alison Thompson
Journal:  RSC Adv       Date:  2019-05-07       Impact factor: 4.036

8.  Prodigiosin analogue designed for metal coordination: stable zinc and copper pyrrolyldipyrrins.

Authors:  Tsuhen M Chang; Sanhita Sinharay; Andrei V Astashkin; Elisa Tomat
Journal:  Inorg Chem       Date:  2014-07-10       Impact factor: 5.165
  8 in total

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