| Literature DB >> 23068989 |
Wen-Jie Li1, Shu-Min Li, Ying Ding, Bing He, Jack Keegan, Hongxin Dong, Jing-Wen Ruan, Yuan-Shan Zeng.
Abstract
Calcitonin gene-related peptide (CGRP) plays a variety of important roles within the nervous system. Increasing CGRP expression could improve the survival of injured neurons and prevent neuronal loss. In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. We then verified this result through exogenous administration of CGRP in a spinal cord transected completely in rats. Finally, we investigated the effect of electro-acupuncture (EA) on CGRP expression following the spinal cord transected completely in rats. We found that EA can improve CGRP expression, and exogenous CGRP may promote the survival of injured neurons, both in vivo and in vitro. Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically.Entities:
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Year: 2012 PMID： 23068989 DOI： 10.1016/j.neuint.2012.10.002
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921