Literature DB >> 23068606

Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.

Kaoru Hazeki1, Kiyomi Nigorikawa, Yuki Takaba, Tomohiro Segawa, Akiko Nukuda, Ayaka Masuda, Yuki Ishikawa, Koji Kubota, Shunsuke Takasuga, Osamu Hazeki.   

Abstract

PtdIns(3)P (phosphatidylinositol 3-phosphate) is a signaling molecule important for phagosome maturation. The major role of Vps34 in production of phagosomal PtdIns(3)P has been indicated. However, the fate of the newly generated PtdIns(3)P has not been well described. Here we show that elimination of PtdIns(3)P from phagosomal membrane was significantly delayed in RAW264.7 macrophages lacking PTEN or PIKfyve. In the PTEN-deficient cells treated with a PIKfyve inhibitor, degradation of PtdIns(3)P was almost lost, indicating that PTEN and PIKfyve are two major players in phagosomal PtdIns(3)P metabolism.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23068606     DOI： 10.1016/j.febslet.2012.09.043

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

Review 1.  Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.

Authors:  Amber J McCartney; Yanling Zhang; Lois S Weisman
Journal:  Bioessays       Date:  2013-10-28       Impact factor: 4.345

2.  The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis.

Authors:  David A Sheffield; Malene R Jepsen; Sandra J Feeney; Micka C Bertucci; Absorn Sriratana; Monica J Naughtin; Jennifer M Dyson; Ross L Coppel; Christina A Mitchell
Journal:  J Biol Chem       Date:  2019-09-22       Impact factor: 5.157

3.  Involvement of class II phosphoinositide 3-kinase α-isoform in antigen-induced degranulation in RBL-2H3 cells.

Authors:  Kiyomi Nigorikawa; Kaoru Hazeki; Ying Guo; Osamu Hazeki
Journal:  PLoS One       Date:  2014-10-30       Impact factor: 3.240

Review 4.  Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis.

Authors:  Andreas Jeschke; Albert Haas
Journal:  Commun Integr Biol       Date:  2016-04-08

5.  pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels.

Authors:  Amriya Naufer; Victoria E B Hipolito; Suriakarthiga Ganesan; Akriti Prashar; Vanina Zaremberg; Roberto J Botelho; Mauricio R Terebiznik
Journal:  J Cell Biol       Date:  2017-10-31       Impact factor: 10.539

6.  PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.

Authors:  Catherine M Buckley; Victoria L Heath; Aurélie Guého; Cristina Bosmani; Paulina Knobloch; Phumzile Sikakana; Nicolas Personnic; Stephen K Dove; Robert H Michell; Roger Meier; Hubert Hilbi; Thierry Soldati; Robert H Insall; Jason S King
Journal:  PLoS Pathog       Date:  2019-02-07       Impact factor: 6.823

7.  Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2.

Authors:  Kiyomi Nigorikawa; Kaoru Hazeki; Junko Sasaki; Yumio Omori; Mikiko Miyake; Shin Morioka; Ying Guo; Takehiko Sasaki; Osamu Hazeki
Journal:  PLoS One       Date:  2015-11-04       Impact factor: 3.240

8.  Transcriptome Co-expression Network Analysis Identifies Key Genes Regulating Conchosporangia Maturation of Pyropia haitanensis.

Authors:  Yinghui Lin; Kai Xu; Yan Xu; Dehua Ji; Changsheng Chen; Wenlei Wang; Chaotian Xie
Journal:  Front Genet       Date:  2021-06-30       Impact factor: 4.599
  8 in total

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