Foot problems in a group of patients with rheumatoid arthritis: an unmet need for foot care.

OBJECTIVES: The aim of this study was to evaluate the foot involvement in a group of RA patients in regard to symptoms, type and frequency of deformities, location, radiological changes, and foot care. PATIENTS AND METHODS: A randomized selected 100 rheumatoid arthritis (RA) patients were recruited to the study. Data about foot symptoms, duration and location of foot pain, pain intensity, access to services related to foot, treatment, orthoses and assistive devices, and usefulness of therapies were determined by the questionnaire. Radiological changes were assessed according to modified Larsen scoring system. The scores of disease activity scale of 28 joints and Health Assessment Questionnaire indicating the functional status of RA patients were collected from patient files.
RESULTS: A total of 100 RA patients (90 female, 10 male) with a mean age of 52.5 ±10.9 years were enrolled to the study. Eighty-nine of the 100 patients had experienced foot complaints/symptoms in the past or currently. Foot pain and foot symptoms were reported as the first site of involvement in 14 patients. Thirty-six patients had ankle pain and the most common sites of the foot symptoms were ankle (36%) and forefoot (30%) followed by hindfoot (17%) and midfoot (7%) currently. Forty-nine of the patients described that they had difficulty in performing their foot care. Insoles and orthopedic shoes were prescribed in 39 patients, but only 14 of them continued to use them. The main reasons for not wearing them were; 17 not helpful (43%), 5 made foot pain worse (12.8%), and 3 did not fit (7.6%). Foot symptoms were reported to be decreased in 24 % of the subjects after the medical treatment and 6 patients indicated that they had underwent foot surgery. Current foot pain was significantly associated with higher body mass index and longer disease duration, and duration of morning stiffness. The radiological scores did not correlate with duration of foot symptoms and current foot pain (p>0.05) but the total number of foot deformities was found to be correlated with Larsen scores (p<0.05).
CONCLUSION: In our study, foot involvement and foot symptoms were seen frequently in RA but there is an unmet need for provision and monitoring of foot care in patients suffering from this chronic disease.

INTRODUCTION

Rheumatoid Arthritis (RA) is a chronic inflammatory disorder affecting primarily cartilage and bone of small and middle-sized joints [1, 2]. The synovial inflammation and destruction of joints lead to pain, loss of function, muscle atrophy that results with disability and reduced quality of life [2, 3]. The frequency of foot involvement and rheumatoid foot problems have previously been reported from different point of views [4-15].

Various types of foot deformities can result according to the pattern of joint involvement in RA. Within the foot, the subtalar and mid-tarsal joints are more frequently involved than the ankle joint. The ankle is usually quite stable, but reduced dorsal flexion may interfere with walking ability. The subtalar and talonavicular joints are commonly affected in RA. Synovitis causes pain and stiffness and sometimes leads to subtalar dislocation. As cartilage loss and bone erosion develop, valgus deformity increases with progressive flattening of the longitudinal arch. Forefoot deformity starts with synovitis of the MTP-joints and the involvement of the flexor tendons. The synovitis and erosion occur in metatarsal heads resulting in joint contractures and dislocation, and can lead to extreme pain. Weight bearing in the active stage of RA, may be followed by hallux valgus, hallux rigidus, mallet toe, claw toe and splay toe deformities. In the midfoot, pes planus is the most commonly seen deformity. Calcaneal varus and valgus deformities can also develop in the hind foot [16-18].

Although patients with RA complain of foot pain and disability due to foot problems, physicians generally overlook or neglect the feet in routine clinical examination. Outcome measures such as the DAS 28, is generally used to assess disease activity and helps to define clinical remission of the disease. Unfortunately, feet and ankles are not included as part of the DAS 28 scoring system and accordingly the feet joints are ignored in routine rheumatologic evaluation and even patients in remission may suffer from foot disease activity, as shown in previous studies [19, 20].

The aim of this study was to evaluate the foot involvement in regard to symptoms, type and frequency of deformities, location, radiological changes, and foot care in a group of RA patients.

PATIENTS AND METHODS

A hundred and twenty-four patients with RA, who met the ACR revised criteria [21] for RA, were enrolled from the outpatient clinics of Ankara Training and Research Hospital, Rheumatology unit of Physical Medicine and Rehabilitation Clinic, between 2010 January and 2010 June. The local ethics committee of Ankara Training and Research Hospital approved the study.

Patients aged<18, and >80 years, having a history of trauma to foot, having comorbid diseases that may relate to foot pain (neuropathy, lumbar radiculopathy, diabetes mellitus, inflammatory rheumatic disease other than RA, and endocrine arthropathies) were not included to the study. 124 patients with rheumatoid arthritis were assessed for eligibility. 4 patients refused to participate in the study and 20 patients were excluded due to age or comorbid diseases. Therefore 100 RA patients were included to the study. Informed consent was obtained from all of the patients.

Demographic characteristics including age, sex, body mass index of all subjects, duration of disease, duration of foot symptoms and drug intake of RA patients were recorded. All patients underwent a clinical interview and physical examination to determine foot related problems and fulfilled a questionnaire assessing the foot problems [6]. Data about foot symptoms, duration and location of foot pain, pain intensity, access to services related to foot (orthopaedics, physiatry, primary care physician), treatment (medical / surgical), interventions for alleviating foot symptoms (orthoses and assistive devices), and usefulness of therapies were determined by this questionnaire. The location of pain in the feet was classified according to ankle, forefoot, mid foot and hind foot. A picture of feet indicating different anatomical sites in the foot was shown and patients were asked to point out the painful areas [6]. In addition a researcher examined the foot by palpation and recorded the tender and painful sites according to the different anatomical regions; including forefoot (the most anterior section of the foot comprising the metatarsal and phalangeal bones, the long bones anterior to the arch of the foot and the bones of the toes), mid foot (the section of the foot in the front of the anklereferring to as the arch and including five articulating bones of the tarsus: the cuboid, navicular and three cuneiform bones), hind foot (the posterior portion of the foot, comprising the region of talus and calcaneus), and the ankle (the region where the foot and the leg meet; talocrural joint). Radiological changes in the foot x-rays of the patients were assessed according to modified Larsen scoring system [22].

The disease activity scores (DAS 28) [23] and scores of Health Assessment Questionnaire (HAQ) [24] indicating the functional status of RA patients and the positivity of rheumatoid factor and anti-CCP were collected from patient files.

Statistical Analysis

Descriptive statistics were performed and indicated as mean ± standard deviation and median (minimum-maximum) for continuous variables. All qualitative data are expressed as frequencies and percentages. The two independent group comparisons were performed by student t test and Mann Whitney U test. Spearman’s rho and Pearson correlation test were used to evaluate correlation between continuous variables and Fisher’s exact outcome chi square test were used to examine the differences between groups in terms of categorical variables. P values less than 0.05 were considered significant. All statistical analyses were done using SPSS for windows version 15.0 program.

RESULTS

Demographic and clinical characteristics of the study population are presented in Table . Seventy-nine (79%) patients were using methotrexate-MTX- (10-20 mg/week) and other disease modifying anti-rheumatic drugs (DMARDs). Of those 22 (27.8%) patients were on sulphasalasine-SSZ-, 34 (43%) patients were on hydroxychloroquine-HCQ-, and 24 patients (30.3%) were on corticosteroid therapy (less than 15 mg/day) in addition to MTX. Twelve (12%) patients were on leflunomide and 9 (9%) patients were on both HCQ and SSZ. Thirty-nine (39%) patients were using non-steroid anti-inflammatory drugs (NSAIDs). Sixty-one patients were using oral MTX, while 18 patients were on subcutaneous MTX therapy.

Eighty-nine of the 100 patients (89%) had experienced foot complaints / symptoms in the past or currently. Foot pain and foot symptoms were reported as the first site of involvement in 14 patients. Sixty-five patients had ankle pain in the past and the most common sites of the foot symptoms in the past were ankle (%36), forefoot (35%) followed by hindfoot (34%) and midfoot (12%). The distribution of current foot pain, physical findings according to sites and foot symptoms are shown in Table . Ankle joint was the most common painful site (%36) in our sample.

The first examining physician for the foot problems was the physiatrist in 54 patients, orthopedic surgeon in 14 patients, and primary care physician for the remaining. Forty-nine of the patients described that they had difficulty in performing their foot care. Insoles and orthopedic shoes were prescribed in 39 patients, but only 14 of them continued to use them. They mostly didn’t satisfy with the silicon insoles that were prescribed to support the medial longitudinal and transverse arches. The main reasons for not wearing them were described as ‘not helpful’ in 17 patients (43%), ‘made foot pain worse’ in 5 patients (12.8%), and ‘did not fit’ in 3 patients (7.6%). Foot symptoms were reported to be decreased in 24 % of the subjects after the medical treatment and 6 patients indicated that they had underwent foot surgery.

According to genders; high rates of foot pain during the past month were reported by both genders with a trend for women to report foot pain more intensively than men but the difference was not statistically significant. The most common foot symptoms and intensity of foot pain according to genders are shown in Table .

No correlation was observed between current foot pain and demographic parameters like age and gender but current foot pain was significantly associated with higher BMI and longer disease duration (r=0.24, p= 0.01, r=0.23, p=0.01). Corticosteroid therapy was correlated with current foot pain (r=0.24, p=0.01).

The radiological scores did not correlate with duration of foot symptoms and current foot pain (p>0.05) but the total number of foot deformities was found to be correlated with Larsen scores (r=0.26, p=0.001). No correlation was observed between HAQ scores and deformities.

DISCUSSION

The studies evaluating foot involvement in RA reported the foot involvement in 56-100% of the patients [4-11, 13-15]. We found a 89% of foot involvement in RA patients, consistent with the previous data. We indicated the most frequent involvement in the ankle and fore foot, followed by hind foot and mid foot currently, in accordance with previous data [6, 8, 11, 12, 24-27]. According to genders the frequency of foot involvement was reported in 91% females and 81% males in some previous studies [6]. In our RA patients the ratios were 94% and 50% for females and males respectively. The most common involvement was ankle in females and ankle and hind foot in males. But our study group was small and not enough to conclude gender differences.

High body mass index or disease duration were found to be correlated with foot problems possibly because of excessive mechanical load and joint damage process, respectively. The duration of the disease and duration of foot pain were nearly the same which may be due to early involvement of foot joints in our sample.

The epidemiology of foot involvement has previously studied in a number of studies, most of them investigated low number of subjects and/or localized foot disease and focusing only on clinical or radiological changes, rather than views and perceptions of the patients with RA [5, 7, 8, 13, 18]. The exceptions were the studies of Otter et al., and Rome et al. [6, 15]. Otter et al. included a large cohort of people with RA in UK was evaluated for foot involvement and access to foot care, in a perspective from the patients [6]. Rome et al. indicated only 24% of patients that have used podiatry service and highlighted the problems of footwear [15]. Also Naidoo et al. explored the perceptions of women with RA regarding their choice of retail footwear and the factors influencing foot wear selection [28]. We have evaluated the foot involvement as clinical, radiological and from the view of subjects in a group of patients suffering from RA. Our study indicates the main types of foot involvement in RA patients associated with their point of view. Our study confirms a high rate of foot problems and comparable data to other reports previously published [10]. Fifty-one percent of the patients in our study reported current non-painful foot problems. This corresponds well with the results of earlier studies, with frequencies of current foot involvement between 77-94% [2, 5, 6, 8, 29-31]. The rate of foot involvement was higher in our study and current foot pain was relatively less common in our cohort, which could be described by the intensive drug use and moderate disease activity status. RA patients reported a range of foot symptoms which varied in both intensity and severity. Among the specific foot deformities studied, hallux valgus/bunion and corns were the most prevalent ones. However, it was difficult to say that these problems were related to RA because of common complaints in the general population. Other findings including swelling in the foot (68%), numbness in the foot (51%), toe nail problems (37%), and ankle pain (36%) may be attributed to RA since their high percentages compared to the low prevalence diagnosis of general population.

In our study we have additionally evaluated RA patients’ perceptions of foot symptoms. Totally 89 % of patients needed professional help for their foot pain and approximately half of the patients described difficulty in performing their foot care. We indicated that most of the patients with foot pain had shared their foot symptoms with their physician, partly with the physiatrist. Foot insoles and orthoses were prescribed by physicians to improve foot function but the adherence to nonsurgical interventions was only 36% in our study. The prescription of insoles was stated as 5-15% [2, 6, 31] of RA patients in previous studies, with an exception Grondal et al. who determined this prescription in two thirds of their patients [8]. The prescription of the insoles and orthopedic shoes were 39% in our study group, comparable to the results of Otter et al. [6] with a prescription rate of 44.2%. But only 14% of our subjects continued to wear these orthoses. Reasons for the limited uptake of special footwear were complex and multifactorial, similar to the previous data [6, 17, 19]. The most common reason for non-adherence was reported as these devices did not improve their symptoms or did not fit well in our RA group. But this was not surprising as previous studies indicated the limited and conflicted evidence of the foot orthoses in improvement of foot pain and functional disability among patients with RA [32, 33]. The orthoses were reported to decrease forefoot pain and rearfoot pain in patients with early-onset RA but were not shown to improve pain levels in advanced disease [28, 33]. Also the cost-effectiveness of foot orthoses in RA patients was suggested to be furtherly clarified [6, 28]. Many people with RA do not wear the prescribed therapeutic footwear, often due to poor fit or unacceptable cosmetic appearances. The appearance and design of the footwear was of considerable consequence for non compliance. Difficulties with the fit of the orthoses to their retail shoes were also emphasized in some previous studies [6, 28, 32]. The non-adherence of the prescription of foot orthoses may also be related to the lack of regular follow-ups and/or poor education of the patients and physicians.

Orthopedic RA-related surgery of the foot has a strong effect on pain and physical function in patients that do not respond to conservative clinical approaches. In intermediate to severe stages of the disease, conventional surgical treatment involves both joint preserving and joint sacrificing surgery to relieve pain and correct deformity in the rheumatoid forefoot [34]. Some previous authors suggest as earlier as but less radical foot surgery [35, 36]. But in recent years, surgical procedures have been decreased in RA patients as shown by Weiss et al. [37]. Surgery had been reported in 5-22 % of the RA patients with forefoot and hindfoot/ankle problems [5, 6, 8, 35-37]. Surgery had been performed in 6 % of our cases, which is similar to some previous data [5, 6, 8]. As the number of patients with foot surgery was small, we could not classify surgeries according to sites and could not compare our patients with the subjects of previous studies [5, 6, 8, 35-37].

Although the foot symptoms and secondary limitations on activities of daily living are common problems in RA patients, the examination of foot is generally neglected in routine clinical practice [6, 8, 9]. Foot examination is an important factor for predicting disability, which is also the main predictor of poor outcome in RA patients. We have indicated that functional status scores are not correlated with current foot pain in our RA patients, similar to some previous data [10, 11]. In our study we have performed HAQ to assess functional status which consists of questions mostly about the upper extremity function and DAS28 to assess disease activity which neglect foot joints. Previous studies using specific foot questionnaires indicated a close relationship between foot symptoms and functional disability [11]. In this study we did not use a specific foot function index which could be a major limitation of the study.

Our study is the first study evaluating foot impairment clinically and from patients’ perspective in a group of Turkish patients with RA, and foot abnormalities are found to be various and common in this population. We have also determined a probable lack of compliance with recommendations and/or education of patients and physicians, as most of the RA patients did not use their orthothic devices.

In conclusion, foot involvement and foot symptoms are seen frequently in RA. Physicians should be encouraged performing the physical examination of the feet, assessment and treatment of foot problems during the follow-ups. Individual proper medication and orthoses should be prescribed by the physicians and the management and compliance to insoles should be monitored as a part of treatment in order to enhance the quality of life of the patients suffering from this chronic condition.

Table 1.

Demographic and Clinical Characteristics of the Study Population

	Mean ±SD or Median (Minimum-Maximum), n=100
Mean age (years)	52.5 ±10.9 (27-79 years)
Sex (F/M)	90 /10
Body mass index (kg/m2)	29.4 ±5.6 (17.1-52.3)
Duration of disease (years)	12 (1-30)
Duration of foot pain (years)	12 (1-35)
Foot pain-VAS (mm)	47 (0-100)
DAS28 score	4.2 (2.7-5.4)
HAQ score	0.25 (0-1.75)
Larsen score	6.0 (0-64)
ESR (mm/hr)	38.0 (13.0-57.0)
CRP (g/dL)	0.7 (0.3-1.9)
RF-positivity %	64
CCP-positivity %	53

Table 2.

The Frequency and Distribution of Current Foot Pain; that was Based on Examination, and Foot Complaints in Patients with Rheumatoid Arthritis

Current Symptom
Pain location	# of Pateints
Forefoot pain	30
Mid foot pain	7
Hind foot pain	17
Ankle pain	36
Non-pain foot complaints	51
Swelling in the foot	68
Numbness in the foot	51
Corns	24
Ulcer	1
Bunion	14
Flat foot	11
Toe nail problems	37
Others	5

Table 3.

Pain Intensity, Location of Foot Pain and Foot Symptoms in the Patients According to the Sex

	Females, n=90 Mean ±SD and Median (Minimum-Maximum)	Males, n=10 Mean ±SD and Median (Minimum-Maximum)	p
Foot pain-VAS	24.6±25.5(median 20)	13.0±19.0 (median 0)	0.183*
Duration of symptoms (years)	10.5±9.0	7.4±7.7	0.243**
Current pain
Current pain in forefoot	30 (33.3%)	0	0.09***
Current pain in midfoot	6 (6.7%)	1 (10%)	0.69***
Current pain in hindfoot	15 (16.7%)	2 (20%)	0.79***
Current pain in ankle	34 (37.8%)	2 (20%)	0.29***
Past pain
Forefoot pain in the past	49 (54.4%)	5(50%)	0.71***
Midfoot pain in the past	8 (8.9%)	0	0.32***
Hindfoot pain in the past	31 (34.4%)	4 (40%)	0.72***
Ankle pain in the past	60 (66.7%)	5 (50%)	0.29***
Corns	21 (23.3%)	3 (30%)	0.83***
Ulcer	1 (1.1%)	0	0.65***
Bunion	13 (14.4%)	1 (10%)	0.45***
Flat foot	11 (12.2%)	0	0.54***
Others	5 (5.6%)	0	0.32***

Mann-whitney U test.

Student-t test.

Fisher’s exact outcome chi square test