Computational opportunities for remote collaboration and capacity building afforded by Web 2.0 and cloud computing.

In this paper, we state our aims and aspirations for building a global network of likeminded people interested in developing and encouraging students in the field of computational biophysics (CB). Global capacity building efforts have uncovered local computational talent in virtually every community regardless of where the students reside. Our vision is to discover and encourage these aspiring investigators by suggesting ways that they and other "garage scientists" can participate in new science even if they have no access to sophisticated research infrastructure. We argue that participatory computing in the "cloud" is particularly suitable for CB and available to any budding computational biophysicist if he or she is provided with open-minded mentors who have the necessary skills and generosity. We recognize that there are barriers to the development of such remote collaborations, and we discuss possible pathways to overcome these barriers. We point out that this Special Issue of Biophysical Reviews provides a much-needed forum for the development of several specific applications of CB.