Literature DB >> 23066186

Preparation and optimization of microemulsion of rosuvastatin calcium.

Zalak B Patel1, Kruti S Patel, Ankit S Shah, Naazneen I Surti.   

Abstract

Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having higher solubility in them. 3:1% w/w S:CoS was selected as it gave higher microemulsion area. Optimized batch (ME-1) was selected having 5% Capmul MCM, 50% Tween 20:PEG 400 and 45% water based on evaluation parameters globule size, zeta potential, PDI, % transmittance.

Entities:  

Keywords:  Microemulsion; bioavailability; solubility enhancement

Year:  2012        PMID： 23066186      PMCID： PMC3467806          DOI： 10.4103/0975-7406.94164

Source DB:  PubMed          Journal:  J Pharm Bioallied Sci        ISSN： 0975-7406


  2 in total

1.  Development of an ethyl laurate-based microemulsion for rapid-onset intranasal delivery of diazepam.

Authors:  Lianli Li; Indranil Nandi; Kwon H Kim
Journal:  Int J Pharm       Date:  2002-04-26       Impact factor: 5.875

2.  Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization.

Authors:  Ramesh Gannu; Chinna Reddy Palem; Vamshi Vishnu Yamsani; Shravan Kumar Yamsani; Madhusudan Rao Yamsani
Journal:  Int J Pharm       Date:  2010-01-07       Impact factor: 5.875
  2 in total
  2 in total

1.  Computationally designed prodrugs of statins based on Kirby's enzyme model.

Authors:  Rafik Karaman; Wajd Amly; Laura Scrano; Gennaro Mecca; Sabino A Bufo
Journal:  J Mol Model       Date:  2013-07-09       Impact factor: 1.810

2.  Improved in vitro and in vivo Anti-Candida albicans Activity of Cymbopogon nardus Essential Oil by Its Incorporation into a Microemulsion System.

Authors:  Luciani Gaspar de Toledo; Matheus Aparecido Dos Santos Ramos; Patrícia Bento da Silva; Camila Fernanda Rodero; Veridiana de Sá Gomes; Anderson Noronha da Silva; Fernando Rogério Pavan; Isabel Cristiane da Silva; Fernando Bombarda Oda; Danilo Luis Flumignan; André Gonzaga Dos Santos; Marlus Chorilli; Margarete Teresa Gottardo de Almeida; Taís Maria Bauab
Journal:  Int J Nanomedicine       Date:  2020-12-29
  2 in total

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