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Literature DB >> 23064368

Amazing IL-9: revealing a new function for an "old" cytokine.

Abstract

The incidence of melanoma - the most aggressive form of skin cancer - is dramatically increasing, while the development of innovative therapeutic strategies continues to be challenging, especially due to a lack of knowledge about the molecular mechanisms underlying melanoma progression as well as antitumor immunity. In this issue of the JCI, Yong Lu and colleagues report a central role for Th9 cells in antitumor immunity.

Entities: Disease Gene

Mesh：

Substances：
Interleukin-9

Year: 2012 PMID： 23064368 PMCID： PMC3484464 DOI： 10.1172/JCI65929

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

20 in total

Review 1. IL-9 and its receptor: from signal transduction to tumorigenesis.

Authors: Laurent Knoops; Jean-Christophe Renauld
Journal: Growth Factors Date: 2004-12 Impact factor: 2.511

2. IL-1 serves as a secondary signal for IL-9 expression.

Authors: E Schmitt; H U Beuscher; C Huels; P Monteyne; R van Brandwijk; J van Snick; E Ruede
Journal: J Immunol Date: 1991-12-01 Impact factor: 5.422

3. IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders.

Authors: R C Levitt; M P McLane; D MacDonald; V Ferrante; C Weiss; T Zhou; K J Holroyd; N C Nicolaides
Journal: J Allergy Clin Immunol Date: 1999-05 Impact factor: 10.793

4. Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations.

Authors: Xiaohong Rose Yang; Ruth M Pfeiffer; William Wheeler; Meredith Yeager; Stephen Chanock; Margaret A Tucker; Alisa M Goldstein
Journal: Int J Cancer Date: 2009-12-15 Impact factor: 7.396

5. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

Authors: R D Leek; C E Lewis; R Whitehouse; M Greenall; J Clarke; A L Harris
Journal: Cancer Res Date: 1996-10-15 Impact factor: 12.701

6. Thymic lymphomas in interleukin 9 transgenic mice.

Authors: J C Renauld; N van der Lugt; A Vink; M van Roon; C Godfraind; G Warnier; H Merz; A Feller; A Berns; J Van Snick
Journal: Oncogene Date: 1994-05 Impact factor: 9.867

7. Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma.

Authors: D Ribatti; M G Ennas; A Vacca; F Ferreli; B Nico; S Orru; P Sirigu
Journal: Eur J Clin Invest Date: 2003-05 Impact factor: 4.686

8. Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice.

Authors: Valeska Heib; Marc Becker; Tobias Warger; Gerd Rechtsteiner; Christine Tertilt; Matthias Klein; Tobias Bopp; Christian Taube; Hansjörg Schild; Edgar Schmitt; Michael Stassen
Journal: Blood Date: 2007-04-19 Impact factor: 22.113

Review 9. Immune therapy for cancer.

Authors: Michael Dougan; Glenn Dranoff
Journal: Annu Rev Immunol Date: 2009 Impact factor: 28.527

10. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.

Authors: Rahul Purwar; Christoph Schlapbach; Sheng Xiao; Hong Soon Kang; Wassim Elyaman; Xiaodong Jiang; Anton M Jetten; Samia J Khoury; Robert C Fuhlbrigge; Vijay K Kuchroo; Rachael A Clark; Thomas S Kupper
Journal: Nat Med Date: 2012-07-08 Impact factor: 53.440

13 in total

Review 1. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.

Authors: Andrzej T Slominski; Anna A Brożyna; Michal A Zmijewski; Wojciech Jóźwicki; Anton M Jetten; Rebecca S Mason; Robert C Tuckey; Craig A Elmets
Journal: Lab Invest Date: 2017-02-20 Impact factor: 5.662

Review 2. Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Authors: Han-Yu Shih; Giuseppe Sciumè; Amanda C Poholek; Golnaz Vahedi; Kiyoshi Hirahara; Alejandro V Villarino; Michael Bonelli; Remy Bosselut; Yuka Kanno; Stefan A Muljo; John J O'Shea
Journal: Immunol Rev Date: 2014-09 Impact factor: 12.988

3. Glycogen synthase kinase-3 promotes T helper type 17 differentiation by promoting interleukin-9 production.

Authors: Dongmei Han; Eva M Medina-Rodriguez; Jeffrey A Lowell; Eléonore Beurel
Journal: Immunology Date: 2020-05-08 Impact factor: 7.397

Review 4. Evolution of the magic bullet: Single chain antibody fragments for the targeted delivery of immunomodulatory proteins.

Authors: Christian Fercher; Sahar Keshvari; Michael A McGuckin; Ross T Barnard
Journal: Exp Biol Med (Maywood) Date: 2017-12-19

Review 5. Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.

Authors: Kiyoshi Hirahara; Amanda Poholek; Golnaz Vahedi; Arian Laurence; Yuka Kanno; Joshua D Milner; John J O'Shea
Journal: J Allergy Clin Immunol Date: 2013-05 Impact factor: 10.793

6. Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges.

Authors: Dominique B Hoelzinger; Ana Lucia Dominguez; Peter A Cohen; Sandra J Gendler
Journal: Cancer Res Date: 2014-10-08 Impact factor: 12.701