OBJECTIVE: To evaluate the effects of household use of cleaning products during pregnancy on infant wheezing and lower respiratory tract infections (LRTI). METHODS: In four prospective Spanish birth cohorts (n = 2,292), pregnant women reported the use of household cleaning products. When infants were 12-18 months old, current cleaning product use and infant's wheezing and LRTI were reported. Cohort-specific associations between the use of specific products and respiratory outcomes were evaluated using multivariable regression analyses and estimates were combined using random-effects meta-analyses. RESULTS: The period prevalence of LRTI was higher when sprays (combined odds ratio (OR) = 1.29; 95 % confidence interval (CI) 1.04-1.59) or air fresheners (OR = 1.29; CI 1.03-1.63) were used during pregnancy. The odds of wheezing increased with spray (OR = 1.37; CI 1.10-1.69) and solvent (OR = 1.30; CI 1.03-1.62) use. The associations between spray and air freshener use during pregnancy and both outcomes remained apparent when these products were not used after pregnancy. Nevertheless, the estimates were higher when post-natal exposure was included. CONCLUSION: The use of cleaning sprays, air fresheners and solvents during pregnancy may increase the risk of wheezing and infections in the offspring.
OBJECTIVE: To evaluate the effects of household use of cleaning products during pregnancy on infantwheezing and lower respiratory tract infections (LRTI). METHODS: In four prospective Spanish birth cohorts (n = 2,292), pregnant women reported the use of household cleaning products. When infants were 12-18 months old, current cleaning product use and infant's wheezing and LRTI were reported. Cohort-specific associations between the use of specific products and respiratory outcomes were evaluated using multivariable regression analyses and estimates were combined using random-effects meta-analyses. RESULTS: The period prevalence of LRTI was higher when sprays (combined odds ratio (OR) = 1.29; 95 % confidence interval (CI) 1.04-1.59) or air fresheners (OR = 1.29; CI 1.03-1.63) were used during pregnancy. The odds of wheezing increased with spray (OR = 1.37; CI 1.10-1.69) and solvent (OR = 1.30; CI 1.03-1.62) use. The associations between spray and air freshener use during pregnancy and both outcomes remained apparent when these products were not used after pregnancy. Nevertheless, the estimates were higher when post-natal exposure was included. CONCLUSION: The use of cleaning sprays, air fresheners and solvents during pregnancy may increase the risk of wheezing and infections in the offspring.
Authors: Jan-Paul Zock; Estel Plana; Josep M Antó; Geza Benke; Paul D Blanc; Aurelia Carosso; Anna Dahlman-Höglund; Joachim Heinrich; Deborah Jarvis; Hans Kromhout; Linnéa Lillienberg; Maria C Mirabelli; Dan Norbäck; Mario Olivieri; Michela Ponzio; Katja Radon; Argo Soon; Marc van Sprundel; Jordi Sunyer; Cecilie Svanes; Kjell Torén; Giuseppe Verlato; Simona Villani; Manolis Kogevinas Journal: J Allergy Clin Immunol Date: 2009-08-08 Impact factor: 10.793
Authors: Catherine Karr; Thomas Lumley; Kristen Shepherd; Robert Davis; Timothy Larson; Beate Ritz; Joel Kaufman Journal: Environ Health Perspect Date: 2006-02 Impact factor: 9.031
Authors: Andrea L Deierlein; Alexis R Grayon; Xiaotong Zhu; Yanwen Sun; Xun Liu; Kaelyn Kohlasch; Cheryl R Stein Journal: Int J Environ Res Public Health Date: 2022-05-06 Impact factor: 4.614