Literature DB >> 23063948

Regulation of voltage-dependent calcium channels by RGK proteins.

Tingting Yang1, Henry M Colecraft.   

Abstract

RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members - Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca²⁺ (Ca(V)1 and Ca(V)2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms, structural determinants, physiological role, and potential practical applications of RGK-mediated inhibition of Ca(V)1/Ca(V)2 channels. This article is part of a Special Issue entitled: Calcium channels.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23063948      PMCID： PMC4190112          DOI： 10.1016/j.bbamem.2012.10.005

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  102 in total

1.  Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.

Authors:  Shoji X Takahashi; Scott Mittman; Henry M Colecraft
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033

2.  Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.

Authors:  Brian S Finlin; Shawn M Crump; Jonathan Satin; Douglas A Andres
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

3.  Preferential closed-state inactivation of neuronal calcium channels.

Authors:  P G Patil; D L Brody; D T Yue
Journal:  Neuron       Date:  1998-05       Impact factor: 17.173

4.  Importance of the different beta subunits in the membrane expression of the alpha1A and alpha2 calcium channel subunits: studies using a depolarization-sensitive alpha1A antibody.

Authors:  N L Brice; N S Berrow; V Campbell; K M Page; K Brickley; I Tedder; A C Dolphin
Journal:  Eur J Neurosci       Date:  1997-04       Impact factor: 3.386

5.  Subunit regulation of the neuronal alpha 1A Ca2+ channel expressed in Xenopus oocytes.

Authors:  M De Waard; K P Campbell
Journal:  J Physiol       Date:  1995-06-15       Impact factor: 5.182

6.  Roles of a membrane-localized beta subunit in the formation and targeting of functional L-type Ca2+ channels.

Authors:  A J Chien; X Zhao; R E Shirokov; T S Puri; C F Chang; D Sun; E Rios; M M Hosey
Journal:  J Biol Chem       Date:  1995-12-15       Impact factor: 5.157

Review 7.  G protein mechanisms: insights from structural analysis.

Authors:  S R Sprang
Journal:  Annu Rev Biochem       Date:  1997       Impact factor: 23.643

8.  Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation.

Authors:  B S Finlin; D A Andres
Journal:  J Biol Chem       Date:  1997-08-29       Impact factor: 5.157

9.  Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.

Authors:  J S Moyers; P J Bilan; J Zhu; C R Kahn
Journal:  J Biol Chem       Date:  1997-05-02       Impact factor: 5.157

10.  Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.

Authors:  Y Ward; B Spinelli; M J Quon; H Chen; S R Ikeda; K Kelly
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272
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  38 in total

1.  Functional assessment of three Rem residues identified as critical for interactions with Ca(2+) channel β subunits.

Authors:  Donald Beqollari; Christin F Romberg; Dilyana Filipova; Symeon Papadopoulos; Roger A Bannister
Journal:  Pflugers Arch       Date:  2015-03-15       Impact factor: 3.657

2.  β-Subunit of the voltage-gated Ca2+ channel Cav1.2 drives signaling to the nucleus via H-Ras.

Authors:  Evrim Servili; Michael Trus; Daphne Maayan; Daphne Atlas
Journal:  Proc Natl Acad Sci U S A       Date:  2018-08-27       Impact factor: 11.205

3.  Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currents.

Authors:  Xingfu Xu; Fangxiong Zhang; Gerald W Zamponi; William A Horne
Journal:  FASEB J       Date:  2015-01-06       Impact factor: 5.191

4.  Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscle.

Authors:  D Beqollari; C F Romberg; U Meza; S Papadopoulos; R A Bannister
Journal:  Biophys J       Date:  2014-05-06       Impact factor: 4.033

5.  N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.

Authors:  J-H Duan; K E Hodgdon; C M Hingtgen; G D Nicol
Journal:  Neuroscience       Date:  2014-04-19       Impact factor: 3.590

6.  Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.

Authors:  Sam Chai; Xiaoping Wan; Angelina Ramirez-Navarro; Paul J Tesar; Elizabeth S Kaufman; Eckhard Ficker; Alfred L George; Isabelle Deschênes
Journal:  J Clin Invest       Date:  2018-02-12       Impact factor: 14.808

7.  Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice.

Authors:  Brooke M Ahern; Bryana M Levitan; Sudhakar Veeranki; Mihir Shah; Nemat Ali; Andrea Sebastian; Wen Su; Ming C Gong; Jiayang Li; Julian E Stelzer; Douglas A Andres; Jonathan Satin
Journal:  J Biol Chem       Date:  2019-05-30       Impact factor: 5.157

8.  The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.

Authors:  Leandro Royer; Josiah J Herzog; Katelyn Kenny; Boriana Tzvetkova; Jesse C Cochrane; Michael T Marr; Suzanne Paradis
Journal:  J Biol Chem       Date:  2018-08-02       Impact factor: 5.157

9.  Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons.

Authors:  Frédérique Scamps; Sina Sangari; Melissa Bowerman; Mathieu Rousset; Michel Bellis; Thierry Cens; Pierre Charnet
Journal:  Pflugers Arch       Date:  2014-05-09       Impact factor: 3.657

10.  Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.

Authors:  Henry L Puhl; Van B Lu; Yu-Jin Won; Yehezkel Sasson; Joel A Hirsch; Fumihito Ono; Stephen R Ikeda
Journal:  PLoS One       Date:  2014-07-03       Impact factor: 3.240
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